Amifostine

Amifostine is used to prevent dryness in the mouth after radiotherapy of head and neck cancer. It is also used to reduce the harmful effect of chemotherapy on the kidneys during treatment with cisplatin (medicine used to treat cancer). Amifostine is given as an injection into vein (IV infusion) under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, vomiting and decreased blood pressure are some common side effects of this medicine. Consult with your doctor if it does not go away or bothers you. It is advised to stay hydrated before taking this medicine. You will be check for blood pressure before infusion and every 5 minutes during infusion. Before taking it, tell your doctor if you have heart disease such as irregular heartbeat and heart failure, or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Amifostine works by removing free radical, harmful elements produced by cisplatin (a medicine used to treat cancer) or radiation therapy in tissues.

• Dryness in the mouth after radio therapy of head and neck cancer

Thiol metabolite binds to reactive metabolites of cisplatin and scavenges free radicals

Adult Dose: Nephrotoxicity 910 mg/m² IV (15-minute infusion), 30 minutes before chemotherapy Blood pressure should be followed following its administration and interrupted if systolic blood pressure decreases signficantly from baseline Xerostomia 200 mg/m² IV (3-minute infusion), 15-30 minutes before radiation therapy 500 mg SC qDay prior to radiation therapy Child Dose: Safety and efficacy not established

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Decreased blood pressure • Hiccup • Sleepiness • Dizziness • Flushing (sense of warmth in the face, ears, neck and trunk) • Fever • Chills

[CONSULT YOUR DOCTOR] It is not known whether Amifostine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Inform your doctor if you suffer from cardiovascular or cerebrovascular conditions such as ischemic heart disease (chest pain, discomfort or frank heart attack), arrhythmias (irregular heartbeats), heart failure, or have a history of stroke or transient ischemic attacks (mini stroke). You need to be adequately hydrated prior to the amifostine infusion. Frequent monitoring of blood pressure is required during infusion and use of antihypertensive drugs 24 hr prior to start of amifostine infusion should be avoided. Tell your doctor if you are or planning to become pregnant or are breastfeeding. Inform your doctor immediately if you develop any skin reaction or reactions in and around the mouth, any time following amifostine administration. Amifostine is not recommended for use in elderly.

Hypersensitivity to aminothiol, monitor closely during and after IV

Special consideration should be given to the administration of Amifostine for Injection in patients receiving antihypertensive medications or other drugs that could cause or potentiate hypotension.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Amifostine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Amifostine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Amifostine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Amifostine is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Amifostine may not be needed in these patients. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Amifostine in patients with liver disease. Please consult your doctor.

Sir mere neck me dard rhta h, me tamaku khaati thi kya Ye cancer k lakshan h Pain may be sign for cancer, do you have any swelling on neck or in mouth along with that I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time. What is care & medicine required after radio therapy and chemotherapy i have attached report after operation Keep regular follow up with your doctor, you can have adcumin syrup. Neck stiffness, Dryness in Mouth, Blankness in Brain change your lifestyle, morning walk ,yoga pranayam, empty stomach 2 glasd of Luke warm water, avoid junk, spicy totally .Start taking . stsaloevera juice+ trifala juice 20 ml twice .brahmi vati 2 tablet twice with Luke warm cow milk.you can also go for Panchkarma therapy Cancer in the neck of my father Send all reports and photos of tumor Injection therapy in erectile d Injectable medication are available which needs to be injected directly into penis consult andrologist nearby for prescription Dryness of mouth felling to drink water again and again after drink water Get ur HbA1c done n review.Betadine gargles thrice daily cough with phelgm, nose block at night, running nose, adenoids grade 2 , neck lymph node mild inrease allergy to cold Main problem can be because of adenoid. Lymph node are due to infection in head and neck region. Take a good long course of antibiotics after consulting with a ENT specialist