Ampicillin + Cloxacillin

Combination of aminopenicillin and penicillinase-resistant penicillin effective against a wide range of gram-positive and gram-negative bacteria.

Respiratory tract infections, urinary tract infections, skin and soft tissue infections, and other bacterial infections.

Penicillin combinations

Aminopenicillin & Penicillinase-resistant penicillin combination

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Blocks peptidoglycan synthesis, causing bacterial cell lysis.

Adults: 250 mg to 500 mg every 6 hours orally. Children: as directed by physician.

Taken on an empty stomach with a full glass of water.

Take as soon as remembered.

Nausea, vomiting, diarrhea, skin rash, allergic reactions.

Use with caution in patients with history of penicillin hypersensitivity or renal impairment.

Hypersensitivity to penicillins or cephalosporins.

Probenecid increases blood levels of ampicillin. Do not mix with aminoglycosides in IV fluids.

Absorption may be reduced by food; take on an empty stomach.

Pregnancy Category B. Use during pregnancy if clearly needed.

Pregnancy Category: B — always consult a doctor before taking during pregnancy.

Excreted in small amounts in breast milk; use with caution.

Safe and effective in children based on weight.

Adjust dosage based on renal function in elderly patients.

Dosage adjustment required in severe renal impairment.

May cause gastrointestinal upset. Symptomatic and supportive treatment.

Store in a cool, dry place protected from light and moisture.

Ampicillin and cloxacillin active pharmaceutical ingredient