Generic
Capreomycin
At a glance
Capreomycin — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Capreomycin is an antibiotic used in the treatment of drug-resistant tuberculosis, in combination with other medicines. It works by stopping the growth of tubercular bacteria which have become resistant to the commonly used first-line medicines. Capreomycin is given as an injection directly into a muscle under the supervision of a healthcare professional. It should be used regularly at evenly spaced time intervals as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. This medicine may lead to kidney damage, balance disorder (loss of balance), and hearing loss. Therefore, please follow all the instructions given by your doctor while using this medicine. Your doctor may monitor you with regular kidney function tests, hearing tests and urine tests during treatment. Consult your doctor if your condition does not improve or if any of the side effects bother you. Use caution while driving or doing anything that requires concentration as this medicine may cause dizziness. It is not recommended for use during pregnancy. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding. Capreomycin is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
Indications
• Tuberculosis (TB)
Mechanism of action
Capreomycin is a cyclic polypeptide antimicrobial. It is bacteriostatic against various Mycobacteria, particularly those that have become resistant to primary anti-TB drugs.
Dosage
Adult Dose: Parenteral Tuberculosis Adult: 1 g daily, by deep IM inj or IV infusion, for 2-4 mth, then 2-3 times wkly for the remainder of the therapy. Max: 20 mg/kg/day.
Administration
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Missed dose
If you miss a dose of Capreomycin, please consult your doctor.
Side effects
Common: • Injection site pain • Renal dysfunction • Balance disorder (loss of balance) • Renal impairment • Hearing loss
Precautions & warnings
[SAFE] Capreomycin does not usually affect your ability to drive. Capreomycin is used for the treatment of tuberculosis, in combination with other medicines. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat. It is given by an injection into a muscle. Use caution while driving or doing anything that requires concentration as Capreomycin may cause dizziness. Your doctor may get regular blood, urine, and hearing tests while you are on this medication. Your doctor will ensure that you are well hydrated before and during treatment with this medicine. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding. Discontinue Capreomycin and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
Contraindications
Hypersensitivity to capreomycin and other aminoglycosides.
Drug interactions
Additive and sometimes irreversible toxic effects w/ other parenteral anti-TB agents (e.g. streptomycin, viomycin). Increased risk of nephrotoxicity and ototoxicity w/ other non-antituberculosis drugs (e.g. polymyxin A sulfate, amikacin, gentamicin, tobramycin, vancomycin, kanamycin, neomycin).
Food interactions
[SAFE] Consuming alcohol with Capreomycin does not cause any harmful side effects.
Use in pregnancy
[CONSULT YOUR DOCTOR] Capreomycin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Capreomycin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
[CAUTION] Capreomycin should be used with caution in patients with kidney disease. Dose adjustment of Capreomycin may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Capreomycin in patients with liver disease. Please consult your doctor. However, regular monitoring of liver function test is advised in patients with liver disease.