osudhkosh

Generic

Cinacalcet

At a glance

Cinacalcet — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Cinacalcet is used to treat high calcium levels in the blood and hyperparathyroidism. It works by controlling the levels of parathyroid hormone (PTH), calcium and phosphorus in your body. Cinacalcet may be used alone or in combination with other medicines. It can be taken with or without food. It should be taken exactly as prescribed by your doctor. Your doctor will decide the dose and how often you should take them. You should take this medicine regularly to get the most benefit from it. Do not stop taking the medicine even if you feel better unless the doctor tells you so. Taking this medicine may cause few common side effects such as nausea, vomiting, dizziness, numbness or tingling sensation, and loss of appetite. Let your doctor know if any of these side effects do not go away with time or get worse, or if you experienced any other symptoms which you think is caused by this medicine. Before using this medicine, inform your doctor if you have any problems with your heart, liver, kidneys, or ever had seizures (fits or convulsions). You should also tell your doctor all the other medications you are taking. If you have low levels of calcium in your body, you should not take this medicine. Your doctor may monitor your blood calcium level while on treatment with this medicine. Pregnant and breastfeeding mothers should ask their doctors' advice before taking this medicine. Cinacalcet works by lowering a chemical (parathyroid hormone), which makes calcium level go back to normal.

Indications

• High calcium levels in the blood • Hyperparathyroidism

Mechanism of action

Cinacalcet is a calcimimetic agent. It lowers parathyroid hormone (PTH) secretion by increasing the sensitivity of the calcium-sensing receptor of the parathyroid gland to activation by extracellular calcium. PTH reduction leads to concomitant decrease in serum calcium and phosphorus concentrations.

Dosage

Adult Dose: Secondary Hyperparathyroidism (HPT) Indicated for secondary HPT in patients with chronic kidney disease on dialysis Initial dose: 30 mg PO qDay May increase if needed by titrating at 2-4 week intervals through sequential doses of 60, 90, 120, or 180 mg qDay Hypercalcemia in Patients with Parathyroid Carcinoma Initial dose: 30 mg PO q12hr May increase if needed at 2-4 week intervals through sequential doses 60 mg q12hr, 90 mg q12hr, or 90 mg q6-8hr as necessary to normalize serum calcium levels Hypercalcemia With Primary Hyperparathyroidism (HPT) Indicated for severe hypercalcemia in patients with primary HPT who are unable to undergo parathyroidectomy Initial dose: 30 mg PO q12hr May increase if needed at 2-4 week intervals through sequential doses 60 mg q12hr, 90 mg q12hr, or 90 mg q6-8hr as necessary to normalize serum calcium levels Renal Dose: Renal Impairment Dose adjustment not necessary

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cinacalcet may be taken with or without food, but it is better to take it at a fixed time.

Missed dose

If you miss a dose of Cinacalcet, skip it and continue with your normal schedule. Do not double the dose.

Side effects

Common: • Vomiting • Nausea

Precautions & warnings

[UNSAFE] Cinacalcet may cause side effects which could affect your ability to drive. Dizziness and seizures have been reported by patients taking Cinacalcet. This may affect your driving ability. Cinacalcet treats hyperparathyroidism and high calcium levels in the blood. It should be taken with or shortly after food. Cinacalcet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. Inform your doctor if you start or stop smoking during treatment with Cinacalcet. Your doctor may monitor your calcium levels regularly during treatment with Cinacalcet. Inform your doctor if you notice signs of low calcium levels such as numbness or tingling around the mouth or muscle aches. Inform your doctor if you have a history of seizures, heart problems, or liver problems.

Contraindications

Hypersensitivity.

Drug interactions

Cinacalcet is a strong CYP2D6 inhibitor and may increase serum concentrations of amitriptyline, nortriptyline and desipramine. Cinacalcet may decrease serum concentrations of tacrolimus. CYP3A4 inhibitors such as ketoconazole, erythromycin may increase plasma concentrations of Cinacalcet.

Food interactions

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Cinacalcet. Please consult your doctor.

Use in pregnancy

[CONSULT YOUR DOCTOR] Cinacalcet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[CONSULT YOUR DOCTOR] Cinacalcet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Renal / hepatic impairment

[SAFE IF PRESCRIBED] Cinacalcet is safe to use in patients with kidney disease. No dose adjustment of Cinacalcet is recommended. [CAUTION] Cinacalcet should be used with caution in patients with liver disease. Dose adjustment of Cinacalcet may be needed. Please consult your doctor.

Common questions

I am very tensed . My parathyroid hormone is very high . PTH - 110.4 . Please help me and suggest me proper medicines . Please advice me as soon as possible . I am also facing respiratory problems , for that i am consulting a doctor but for PTH please help me .
In primary hyperparathyroidism, an enlargement of one or more of the parathyroid glands causes overproduction of the hormone, resulting in high levels of calcium in the blood (hypercalcemia), which can cause a variety of health problems. Surgery is the most common treatment for primary hyperparathyroidism I have a lot of pain in one of my feet for last one month. Pain arises if I stand or walk for more than 10 mins. Since childhood, I have had low calcium levels but now according to this report it high. What can be the reason and what shall I do? have u checked ur some other blood testi need Vitamin D estimation and PTH estimation , also ANA, RA factor, CBC, ESR, serum Creatinine, Hba1c Severe headache since 3 months with hyperthyroidism and PTH level 455 Sir what is treatment start tab tryptomer 10 mg at nite; get mri brain Blood sugar levels high suggest me A person can control his or her sugar levels by regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOU DOCTOR AND LOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you souls not treat it as disease but start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications.online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET Blood Sugar levels high Fasting 207 PP 357 How to bring the levels down? Need to proper investigate and examine. So plz consult doctor nearby.or you can consult me at snergy multiple speciality clinic RD CITY ,BALJEET COMPLEX NEAR SRS MARKET SECTOR 52 gurgaon 9XXXXXX .Advice to maintain calories intake as per weight ,regular walk or aerobic exercises ,on time take your medicines and once a month visit your diabetologist for routine examination and investigations. Will definitely controlled your sugar and u can live healthy life. ##High blood Uric Acid levels. What exactly u want to know i have high homocystine levels even my blood levels counts are irregular. how do they affect my health and what should I do about them Add vit b12 n folic acid tablet cut down carbs n regularly exercisr Hello dr. I often gets muscle cramps in my right hand which usually starts from Palm and then reaches upto elbow Get CBC and Blood Calcium and B12 levels checked
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.