osudhkosh

Generic

Colistin

At a glance

Colistin — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Colistin is an antibiotic that fights bacteria. It is used to treat severe bacterial infections of the body. It is commonly used for critically ill patients admitted to the hospital. Colistin is given under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like stomach upset, slurred speech, dizziness, vertigo, generalized itching, rash, nephrotoxicity, and local redness or swelling at the site of injection. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or does not go away. Before starting treatment with this medicine, you should tell doctor if you are allergic to any antibiotic or have any liver or kidney problems. Pregnant or breastfeeding mothers should consult their doctor before using it. Your doctor may get regular blood tests done to monitor kidney function and the level of the medicine in your blood. Colistin is an antibiotic. It kills bacteria by destroying the bacterial cell membrane.

Indications

• Severe bacterial infections

Mechanism of action

Colistin sulfate is a polymyxin antibiotic which is active against aerobic gram-negative bacteria including most enterobacteria except Proteus, Providentia and Serratia. Susceptible organisms include P. aeruginosa, Legionella spp, H. influenzae, Acinetobacter, V. cholera, Salmonella, Shigella and Pasteurella. Colistin sulfate is used orally while colistimethate sodium is used parenterally or via inhalational route.

Dosage

Adult Dose: Oral Bowel sterilisation; Gastrointestinal infections Adult: As colistin sulfate: 1.5-3 MIU tid. Child: As colistin sulfate: <15 kg: Not suitable; 15-30 kg: 0.75-1.5 MIU tid. Parenteral Severe Gram-negative infections Adult: As colistimethate Na (strength expressed in terms of colistin base): 2.5-5 mg/kg/day in 2-4 divided doses. Max: 5 mg/kg/day. Inhalation Adjunct to antimicrobial therapy in resp infections As colistimethate Na: 1-2 million units twice daily. Max: 2 million units 3 times/day for up to 3 mth in frequent recurrent infections. Child Dose: Oral Bowel sterilisation; Gastrointestinal infections Child: As colistin sulfate: <15 kg: Not suitable; 15-30 kg: 0.75-1.5 MIU tid. Parenteral Severe Gram-negative infections Child: IV, IM 2.5–5 mg base/kg/day based on IBW q8h Up to 5–7 mg base/kg/day Renal Dose: Renal impairment: CrCl (ml/min) 20-50 1-2 million units every 8 hr. 10-20 1 million units every 12-18 hr. <10 1 million units every 18-24 hr

Administration

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Side effects

Common: • Upset stomach • Rash • Paresthesia (tingling or pricking sensation) • Dizziness • Slurred speech • Vertigo • Fever

Precautions & warnings

[UNSAFE] Colistin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Colistin 3Million IU Injection is an antibiotic that is usually only given in the hospital for serious infections. It is given by injection or drip (infusion) into a vein usually over 30-60 minutes. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect. Inform your doctor if it doesn't stop or if you find blood in your stools. Your doctor may get regular blood tests done to monitor the level of the medicine in your blood.

Contraindications

Hypersensitivity. Anuria; porphyria; myasthenia gravis. Pregnancy and lactation.

Drug interactions

Potentiates chloramphenicol and trimethoprim. Potentially Fatal: Potentiates action of curariform muscle relaxants. Potentiates nephrotoxicity of aminoglycosides and cephalothin.

Food interactions

[SAFE] Consuming alcohol with Colistin does not cause any harmful side effects.

Use in pregnancy

[CONSULT YOUR DOCTOR] Colistin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[SAFE IF PRESCRIBED] Colistin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Renal / hepatic impairment

[SAFE IF PRESCRIBED] Colistin is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Colistin may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Colistin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Colistin may not be needed in these patients. Please consult your doctor.

Common questions

Hi I am 20 wk pregnent and just diagnosed with severe low levels of Vitamin D3 to be 5.67. I am taking 4000 IU of D3 (Ultra D3 4K tablet). I have two questions : 1.What does its implications. 2. Is the dose correct
Along with it take 2 shots of Injection Arachitol 6Lac IU at an interval of 2 weeks PATIENT 14 months girl. she have frequently loose motion. Colistin, Tufpro, zinc, have been given. No improvement. Kindly give your suggestions. Vomiting Loose motion. If it?s a breastfed baby, breastfeed as and when the baby demands. It helps to restore the water lost from the body. If the baby is formula fed or above 6 months, ORS could be given. ORS packets are easily available in medical stores. If the ORS packets are not available, 1 teaspoon of sugar and equal amount of salt can be mixed in the cooled boiled water and provided after each bowel movement. This helps to restore the lost ions and water from the body.There are many underlying causes of Patient?s symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Advice given without doing clinical examination can be imperfect or some time harmful to patient. Scar on face due to bacterial infections Pic is not clear, plz visit for proper opinion Dr said she is having rickets.she is very normal .but she was having pain while walking in her knees and ankles fromsomeday i want to know will she be 100%alright after treatment . has prescribed a shellcal daily and a d3 60weekly Take the above treatment Along with this take an Injection of Vitamin-D (Arachitol) 6lakh IU Why this injection Wepox 10000 Iu given? What is the salt in it I have a history of recurring yeast and bacterial vaginosis infections. Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days My father has low Vitamin D. He has been struggling with swelling and pain in the right knee and the left ankle for about a month now. We have consulted a General Physician. Vitamin D level is 6.5 and the X Ray report shows degenerative changes. Take two shots of Injection Arachitol 6Lac IU at an interval of 2 weeksAlso share x-ray pic I have a vitamin d3 deficiency and suffering from severe back pain. I have taken cholecalciferol granules 10000 IU with doctor advise.Every week 1 sachet for first month and 1 sachet for next 5 months. However, this doesnt help. I am afraid if this is going to affect my regular life. Take Cap Sunbless 60k once weekly and Cap Osteo-plus once daily for 3 monthsAlso take 2 shots of Injection Arachitol 6Lac IU at a gap of 1 month
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.