Essential Amino Acid, D-Sorbitol and Electrolytes

Essential Amino Acid, D-Sorbitol and Electrolytes is recommended for provision of amino acids and energy in patients who require intravenous nutrition. Such conditions include surgery, infections, trauma, burns, prolonged disorders of the gastrointestinal tract, hypoproteinemia, malnutrition, preparation of patients for surgery, chemotherapy or radiation therapy, prolonged coma or refusal to eat.

This solution provides crystalline amino acids to promote protein synthesis and wound healing and to reduce the rate of endogenous protein catabolism.

• Post-surgical nutrition: Used for providing nutrition to patients after surgery.
• Infections, Trauma and Burns: Used for providing nutrition to critically ill patients.
• Gastrointestinal disorders: Used for providing nutrition to patients with prolonged GI problems.
• Hypoproteinemia and Malnutrition: Used for treatment of protein deficiency and malnutrition.
• Chemotherapy and Radiation Therapy: Used for providing nutrition during cancer treatment.

Parenteral nutritional preparations

Amino Acids + Electrolytes

Amino acid injection with electrolytes provides crystalline amino acids to promote protein synthesis and wound healing and to reduce the rate of endogenous protein catabolism. Amino acid injection with electrolytes given by central venous infusion in combination with concentrated dextrose, electrolytes, vitamins, trace metals, and ancillary fat supplements, constitutes total parenteral nutrition (TPN).

The amino acids in this solution promote protein synthesis and wound healing and reduce the rate of endogenous protein catabolism.

Adult Dose:

• Maintenance: 0.8-1.0 g/kg/day protein
• Catabolic states: 1.2-2.0 g/kg/day protein
• Usual dosage: 500 mL IV infusion over 200-250 minutes (40-30 drops/min)
• Max daily dose (sorbitol): Should not exceed 100 g

Dose adjustment: Should be increased or decreased according to age, body weight and severity of condition. Infusion rate should be slowed in elderly and severely ill patients.

Administer intravenously. Slow intravenous administration is recommended. Infusion rate should be slowed in elderly and severely ill patients.

If you miss a dose, please consult your doctor.

Side Effects:

• Hypersensitivity
• Chest discomfort and palpitations
• Nausea
• Vomiting
• Chills
• Fever
• Phlebitis
• Electrolyte imbalance

Precautions:

• Use with caution in patients with severe hepatic and renal disorders.
• Use with caution in patients with diabetes mellitus.
• Use with caution in elderly patients.
• Caution required in hereditary fructose intolerance, hepatic coma, azotemia, congestive cardiac failure, severe acidosis and disturbances of amino acid metabolism.

Contraindications:

• Hypersensitivity to any ingredient
• Hereditary fructose intolerance
• Hepatic coma
• Azotemia
• Congestive cardiac failure
• Severe acidosis
• Disturbances of amino acid metabolism

Drug Interactions: At the recommended dosage, the amino acids have no pharmacological effects and are not expected to interact with other medicaments.

Food Interactions: It is not known whether it is safe to consume alcohol with this solution. Consult your doctor.

Use in Pregnancy: Should be used after careful assessment and only if therapeutic benefits outweigh potential risks.

Use in Lactation: Information regarding use during breastfeeding is not available. Consult your doctor.

Pediatric Use: No specific dosage recommendations for children.

Geriatric Use: Use with caution in elderly patients; slow infusion rate.

Renal Impairment: Use with caution in patients with kidney disease.

Hepatic Impairment: Use with caution in patients with liver disease.

Overdose: Limited information is available on overdose. Electrolyte imbalance may occur. Seek medical attention.

Storage: Protect from light and store at controlled room temperature. Avoid freezing. Keep out of reach of children.

Essential Amino Acid + D-Sorbitol + Electrolytes