Generic
Estradiol 0.06% vag prep
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At a glance
Estradiol 0.06% vag prep — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Estradiol 0.06% vag prep is a female sex hormone (estrogen). This is a type of hormone replacement therapy (HRT) that is used to treat symptoms associated with menopause (hot flushes, vaginal dryness, and itching); estrogen deficiency; and thinning of bones (osteoporosis). In some cases, Estradiol 0.06% vag prep is also used to treat breast cancer and prostate cancer along with other anticancer medicines. It is to be taken at a fixed time(s) daily. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. If you have missed a dose, take it as soon as you remember it. Do not skip any dose and finish the full course of treatment. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine. The most common side effects of this HRT are headaches, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. Some of the warning signs and symptoms that need immediate medical attention are breast lumps, unusual vaginal bleeding, dizziness and faintness, severe headaches, chest pain, shortness of breath, pains in your legs, etc. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body. Estradiol 0.06% vag prep is an estrogen (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).
Indications
• Hormone replacement therapy • Post menopausal osteoporosis
Mechanism of action
Estradiol is a naturally occurring oestrogen. Oestrogens are responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH and FSH through a negative feedback system.
Dosage
Adult Dose: Vaginal Vulvular and vaginal atrophy Adult: Insert 2-4 g/day of vag cream intravaginally for 2 wk, then reduce gradually to half the initial dose for 2 wk followed by a maintenance dose of 1 g 1-3 times/wk. Postmenopausal vaginal atrophy Adult: Insert a vag ring containing 2 mg of estradiol and keep in place for 90 days. Urogenital symptoms Adult: Insert a vag ring containing 2 mg of estradiol and keep in place for 90 days. Atrophic vaginitis Adult: Initial: Insert 1 tab (20 mcg) once daily for 2 wk. Maintenance: Insert 1 tab twice wkly. Attempt to discontinue or taper medication at 3-6 mthly intervals.
Administration
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying
Side effects
Common: • Headache • Abdominal cramp • Breast pain • Vaginal spotting • Nausea • Vomiting • Bloating
Precautions & warnings
No interaction found/established You have been prescribed Estradiol 0.06% vag prep as a part of hormone replacement therapy to relieve symptoms of menopause. It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures. Take it at the same time everyday to help you remember to take it. Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Estradiol 0.06% vag prep. It may increase the risk of breast cancer. Have regular breast examinations. Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.
Contraindications
Hypersensitivity; undiagnosed vag bleeding; thrombophloebitis or thromboembolic disorders; breast carcinoma except in selected patients being treated for metastatic disease; oestrogen-dependent tumor; porphyria; pregnancy.
Drug interactions
CYP1A2 and CYP3A4 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol. May enhance the effects of hydrocortisone and prednisolone when used together.
Food interactions
No interaction found/established
Use in pregnancy
[UNSAFE] Estradiol 0.06% vag prep is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Use in lactation
[SAFE IF PRESCRIBED] Estradiol 0.06% vag prep is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
No interaction found/established No interaction found/established
Common questions
I have been told by doctors I have cystitis also simple cyst in right ovary . What should I be doing its been two years I have this issue Hi PATIENT hormone therapy helps with cysts. Ask your doctor for a hormone replacement. Having urine burning problem past month. with the homeop medicine 70% relief i got. now i stopped medicine to have. five year back hystectomy done overies still remain. due to computer work eyes get dried and tired. shoulders also pain. past 1.7 year back pain started. some time hot flashes also come suddenly. all blood investigation and u/s are normal. as per dr. advise take sweet less. hair fall are more. no dandruff. It is normal to have hot flashes and these post menopausal symptoms after hysterectomyYou can take hormone therapy if you want however symptoms will recurrent when you stop treatment Hello Dr. My mother is 63 years old and her weight is appx. 68 kg. She is suffering from osteoporosis arthritis. I consult to many doctors all suggest me for joint replacement. I want to know, is joint replacement is successful treatment in such age group. yes, you can go for bone replacement therapy. there is no harm in it. Ovaries taken out chest pain and intense sweat high heart beats These are the symptoms of menopause. Consult a gynaec nearby and discuss about post menopausal therapy I had hot flash, sweating and ganrahat Seems like post menopausal syndrome. Visit a gynaecologist. Need physio therapy post Knee surgery Contact nearest i am from lucknow Hello Dr. My mother is 63 years old and her weight is appx. 68 kg. She is suffering from osteoporosis arthritis. I consult to many doctors all suggest me for joint replacement. I want to know, is joint replacement is successful treatment in such age group. Dear sir it depends from case to case. Hello Dr. My mother is 63 years old and her weight is appx. 68 kg. She is suffering from osteoporosis arthritis. I consult to many doctors all suggest me for joint replacement. I want to know, is joint replacement is successful treatment in such age group. Kindly consult to any good Ayuvedic Panchkarma center. Panchkarma therapy will give you some result .