Ganirelix

Ganirelix is an anti-gonadotropin-releasing hormone medicine. It is used in the treatment of infertility in females. It restricts eggs to release directly and prevents premature ovulation. Ganirelix is injecting directly into the skin under the supervision of a doctor. Do not self administer the injection. Your doctor or nurse may help you to know the best way to inject the medicine at home. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include injection site reaction (redness, itching, and irritation), vaginal bleeding and nausea. To overcome irritation at the injection site, use a different injection site every day to inject the medicine. Some side effects may mean you should inform your doctor immediately include dizziness, faint, abdominal pain, and vomiting. Before taking this medicine, tell your doctor if you have ever had liver or kidney disease or if you are breastfeeding to a baby. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. In females undergoing treatment for infertility, sometimes premature ovulation can lead to the release of those eggs which are not ready for fertilization. Ganirelix blocks the action of a natural hormone and prevents premature release of the eggs from the ovary.

• Female infertility

Ganirelix is a gonadorelin (gonadotrophin-releasing hormone) antagonist. It competitively blocks the gonadotropin-release hormone receptors on the pituitary gonadotroph and transduction pathway. This suppresses gonadotropin secretion and luteinising hormone secretion thus preventing ovulation until the follicles are of adequate size.

Adult Dose: Subcutaneous Female Infertility 250 mcg SC qDay during mid-to-late follicular phase after initiating follicle-stimulating hormone on day 2 and 3 of the cycle, continue therapy until day of hCG administration Hepatic impairment: Moderate to severe: Contraindicated. Renal Dose: Renal impairment: Moderate to severe: Contraindicated.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Injection site reaction • Headache • Nausea • Ovarian hyperstimulation syndrome • Abdominal pain • Vaginal bleeding

[CONSULT YOUR DOCTOR] It is not known whether Ganirelix alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Ganirelix helps prevent premature ovulation in women undergoing assisted reproduction treatments such as IVF. It is injected under the skin (subcutaneously), preferably of the upper leg. Inform your doctor immediately if you get very dizzy, faint, vomit, or have diarrhea while using this medicine. These could be symptoms of ovarian hyperstimulation syndrome (OHSS). Do not use this medicine if you are already pregnant or breastfeeding.

Hypersensitivity, pregnancy, lactation, moderate to severe renal or hepatic impairment.

May require dose adjustment of exogenous gonadotropins when concomitantly used during controlled ovarian hyperstimulation.

[CAUTION] Caution is advised when consuming alcohol with Ganirelix. Please consult your doctor.

[UNSAFE] Ganirelix is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[UNSAFE] Ganirelix is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Ganirelix should be used with caution in patients with kidney disease. Dose adjustment of Ganirelix may be needed. Please consult your doctor. Use of Ganirelix is not advised in patients with moderate to severe kidney disease patients. [CAUTION] Ganirelix should be used with caution in patients with liver disease. Dose adjustment of Ganirelix may be needed. Please consult your doctor. Use of Ganirelix is not advised in patients with moderate to severe liver disease patients.

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