Hyaluronidase

Hyaluronidase is used as a preservative in combination with other medicines. It also helps the medicine to absorb completely by the cells in the body and increases the potency of the medicine. Generally, Hyaluronidase comes in combination with injectable medicines. It must be administered as per prescription under the supervision of a healthcare professional. You should not take the medicine if you have any known allergy from this medication. It is a safe medicine and has minimal or no side effects. However, some people may experience injection site redness, swelling, and pain that goes away with time. Hyaluronidase increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.

• Preservative

Hyaluronidase is an enzyme which reduces the viscosity of ground substance, thus making the tissues more permeable to injected fluids. It facilitates distribution and absorption of locally injected substances. It also promotes resorption of excess fluids and extravasated blood in the tissues.

Adult Dose: Skin Test 0.02 (3 units) of 150 units/mL solution intredermally; a wheal with pseudopods appearing within 5 min and persisting for 20-30 min with itching will indicate positive hypersensitivity reaction Absorption/Dispersion of Injected Drugs Add 50-300 units (typically 150 units) to the injection solution Hypodermoclysis Amphadase/Hylenex: Inject 150 units prior to SC fluid administration; this will facilitate absorption of 1000 mL or more of solution Vitrase: Inject 200 units prior to SC fluid administration; this will facilitate absorption of 1000 mL or more of solution Adjunct Subcutaneous Urography Improves resorption of radiopaque agents; indicated when intravenous administration cannot be successfully accomplished, with the patient prone Inject 75 units SC over each scapula, followed by injection of the contrast medium at the same sites Child Dose: Skin Test 0.02 (3 units) of 150 units/mL solution intradermally; a wheal with pseudopods appearing within 5 min and persisting for 20-30 min with itching will indicate positive hypersensitivity reaction Hypodermoclysis Children > 3 years: May be added to small volumes of solution (up to 200 mL), such as or solutions of drugs for SC injection Infants and children < 3 years: Volume of a single clysis should be limited to 200 mL For premature infants or during the neonatal period: Do not exceed a daily dosage of 25 mL/kg of body weight; rate of administration should not be greater than 2 mL/min Adjunct in Subcutaneous Urography Used when IV administration cannot be successfully accomplished, particularly in infants and small children, with the patient prone Inject 75 units SC over each scapula, followed by injection of the contrast medium at the same sites

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Hyaluronidase, skip it and continue with your normal schedule. Do not double the dose.

Common: • Hives • Hormone imbalance • Allergic reaction • Slow growth in children and teenagers • Angioedema (swelling of deeper layers of skin) • Dizziness • Injection site reaction • Edema (swelling)

[SAFE] Hyaluronidase does not usually affect your ability to drive. Hyaluronidase helps with the absorption of injections that are given into a muscle or under the skin. It may also be used to enable excess fluids and blood in the tissues to be more easily re-absorbed. Your doctor or nurse will give the injection either into a muscle or under the skin. It may cause temporary irritation, swelling or bruising at the injection site. Inform your doctor if this persists. Inform your doctor if you are pregnant or breastfeeding.

Hypersensitivity, malignancy. Direct application to the cornea, reduction of swelling of bites or stings. Inj into or around infected area. IV admin; unexplained premature labour.

Action potentiated by urokinase especially in the treatment of MI. May increase absorption and toxicity of local anaesthetics. Heparin, salicylates and NSAIDs may inhibit the spreading action and efficacy of hyaluronidase.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Hyaluronidase. Please consult your doctor.

[CONSULT YOUR DOCTOR] Hyaluronidase may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Hyaluronidase during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Hyaluronidase in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Hyaluronidase in patients with liver disease. Please consult your doctor.

Can we continuously use lubricating eye drops for prolonged period of time Yes u can. . If it&#x27;s preservative free I got Lasik done on 3rd May 2016 and I&#x27;m still experiencing the post-lasik dry eye. I have been prescribed by the doctor Systane Ultra" eye drops 4 times a day and I&#x27;m willing to go for a lesser expensive alternate - Ocumoist. Please suggest if it is okay to use this alternative - as I also worry about intoxicating my eyes with preservatives." U can use it. Systane ultra is preservative free. U can use refresh tears eyedrop which is also preservative free Diabetic macular edema treatment Laser or antivegf injection Hi sir,i affected chicken pox now 21 days over now i accidently cut my hand now dt injection advisable? Take tetanus injection Im Me grand mother is suffering from vomiting and loose motion. So we gave her domstal 10 mg but immediately after giving she vomitted give him injection Ondem 4mg Which treatment should I take for trigger finger Sir/ madam, i don&#x27;t get any information yet. Steroid injection or surgical release 4 years to go of marriage. 3rd IUI treatment is in flow at hedgewar rugnalaya aurangabad MH. But no any result. Now I give Folisurge 300 i.u. Injection. i confuse about injection. Injection is for ovulation induction I always faint while getting injection, even i don&#x27;t have any problem, what should i do for that ?? it could be just simple phobia for injection, just dont look while u taking injection, think of something else