Nimotuzumab

Nimotuzumab is used in the treatment of head and neck cancer and cancer of colon and rectum. It helps to mark the cancer cells for destruction by the body's immune system. Nimotuzumab is given as an injection under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. Do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include weakness, vomiting, dizziness, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Inform your doctor if you experience sudden difficulty breathing, shortness of breath, and fever, chills. Regular blood tests are required to check your blood cells along with heart, liver and electrolyte levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Nimotuzumab is a monoclonal antibody that specifically binds to receptors on cancer cells. Thus it flags the cancer cells for destruction by the body's immune system.

• Head and neck cancer • Cancer of colon and rectum

Nimotuzumab is a humanised monoclonal antibody which requires bivalent binding for stable attachment to the cell surface. It is therefore bound selectively to cells w/ high levels of the epidermal growth factor receptor (EGFR) expression. Nimotuzumab inhibits epidermal growth factor (EGF) binding and tumour cell growth.

Adult Dose: Intravenous Malignant glioma Adult: 200 mg wkly as continuous IV infusion w/in 60 min in combination w/ radiation treatment of 2 Gy once daily, 5 days/wk to a total dose of 50-60 Gy for 6 wk. Child Dose: Intravenous Malignant glioma Child: As monotherapy in 2 consecutive phases. Induction phase: 150 mg/m2 BSA wkly for 6 wk. After induction phase, patients w/o progressive disease upon 8th-wk evaluation will be treated in the consolidation phase, where it is given 150 mg/m2 BSA every 3 wk until disease progression. Administer via continuous IV infusion w/in 30 min.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Nimotuzumab, please consult your doctor.

Common: • Weakness • Vomiting • Dizziness • Blood in urine • Diarrhea

[CONSULT YOUR DOCTOR] It is not known whether Nimotuzumab alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.

Hypersensitivity. Pregnancy and lactation.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Nimotuzumab. Please consult your doctor.

[CONSULT YOUR DOCTOR] Nimotuzumab may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Information regarding the use of Nimotuzumab during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Nimotuzumab in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Nimotuzumab in patients with liver disease. Please consult your doctor.

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