Nizatidine

Nizatidine is an antacid. It reduces the amount of excess acid made by your stomach. It is used to treat and prevent heartburn, indigestion and other symptoms caused by too much acid in the stomach. It is also used to treat and prevent stomach ulcers, reflux disease and some other rare conditions. Nizatidine is also commonly prescribed to prevent stomach ulcers and heartburn caused due to the use of pain-killers. It must be swallowed whole with water before or after a meal. The medicine must be taken in dose and duration advised by the doctor. This medicine should relieve indigestion and heartburn within a few hours. If the symptoms persist or get worse even after 14 days of treatment, you should consult your doctor immediately. It is not recommended to take this medicine in severe stomach disease. You can help the medicine work better by eating smaller meals more often and avoiding spicy or oily foods. Most people do not experience any side effects while taking this medicine. However, the most common side effects include fatigue, drowsiness, headache, constipation, diarrhea, and muscle pain. These symptoms are usually mild and will go away when you stop taking this medicine or as you adjust to it. Consult your doctor if any of these side effects bother you or do not go away. Before taking it, inform your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you. Also, tell your doctor if you are taking other medications. This medicine is usually considered safe to take during pregnancy and breastfeeding if it has been prescribed by a doctor. Avoid drinking alcohol as this can increase the amount of acid in your stomach and make your symptoms worse. Nizatidine is a histamine H2 receptor antagonist. It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

• Gastroesophageal reflux disease (Acid reflux) • Peptic ulcer disease

Nizatidine is a histamine H2-receptor antagonist. It blocks histamine H2-receptors on gastric parietal cells resulting in decreased gastric acid secretion, gastric volume and hydrogen ion concentration.

Adult Dose: Oral Benign gastric and duodenal ulceration; NSAID-associated ulceration Adult: 300 mg at bedtime or in 2 divided doses for 4-8 wk. Maintenance: 150 mg at bedtime. Gastro-oesophageal reflux disease Adult: 150-300 mg bid for up to 12 wk. Child Dose: GERD <12 years: 5-10 mg/kg/day PO divided q12h Renal Dose: Renal impairment: CrCl (ml/min) Dosage Recommendation <20 150 mg every other day. Maintenance: 150 mg every 3 days. 20-50 150 mg/day. Maintenance: 150 mg every other day.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Nizatidine may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Nizatidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Fatigue • Drowsiness • Headache • Constipation • Diarrhea • Muscle pain

[SAFE] Nizatidine does not usually affect your ability to drive. Take Nizatidine before going to bed if you are taking this medicine once a day. It is very effective in controlling stomach acid that is released when you are asleep. If you are also taking other medications to treat acidity (e.g., antacid), take them 2 hours before or after taking Nizatidine. Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion. Inform your doctor if you do not feel better after taking Nizatidine for 2 weeks as you may be suffering from some other problems. Inform your doctor if you have ever been diagnosed with kidney disease as dose of your medicine may need to be adjusted. Do not stop taking the medication without talking to your doctor.

Hypersensitivity.

May increase absorption of aspirin when used in high-doses. May decrease bioavailability w/ antacids.

[UNSAFE] It is unsafe to consume alcohol with Nizatidine.

[SAFE IF PRESCRIBED] Nizatidine is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Nizatidine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Nizatidine should be used with caution in patients with kidney disease. Dose adjustment of Nizatidine may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Nizatidine in patients with liver disease. Please consult your doctor.