Piperacillin

Piperacillin is an antibiotic medicine used in the treatment of severe bacterial infections. It is also used before certain surgeries to prevent bacterial infections. Piperacillin is given as a drip (intravenous infusion) or as an injection under the supervision of a healthcare professional. It should be used regularly as prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The most common side effects of Piperacillin include allergic reaction, and injection site reactions (pain, swelling, redness). These are usually mild but let your doctor know if they bother you or last more than a few days. It may also cause diarrhea as its side effect. Taking probiotics along with this medicine may provide help. Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your doctor know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it. Piperacillin is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Bacterial infections • Severe bacterial infections

Piperacillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Adult Dose: Parenteral Usual Dosage Range IV: 3-4 g/dose q4-6hr; not to exceed 24 g/24hr IM: 2-3 g/dose q6-12hr; not to exceed 24 g/24 hr Urinary Tract, Uncomplicated 6-8 g/day IV/IM (100 to 125 mg/kg/day) divided q6-12 hr Community-Acquired Pneumonia 6-8 g/day IV/IM (100 to 125 mg/kg/day) divided q6-12 hr Acute Cholangitis 4 g IV q6hr Moderate Infections 2-3 g/dose IV/IM q6-12hr; not to exceed 2 g IM/site Severe Infections 3-4 g IV/IM q4-6hr; not to exceed 24 g/24 hr Uncomplicated Gonorrhea 2 g once with 1 g probenecid 30 min before injection Pseudomonas Infections 4 g IV/IM q4hr Child Dose: Usual Dosage Range Neonates: 100 mg/kg IV/IM q12hr Infants and Children: 200-300 mg/kg/day IV/IM divided q4-6hr Cystic Fibrosis 350-500 mg/kg/day IV/IM divided q4-6hr Renal Dose: Renal Impairment CrCl 20-40 mL/min: 3-4 g q8hr CrCl <20 mL/min: 3-4 g q12hr

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Injection site reactions (pain, swelling, redness) • Allergic reaction

[SAFE] Piperacillin does not usually affect your ability to drive. Piperacillin is used to treat infections caused by bacteria. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect. Taking probiotics along with Piperacillin may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Stop taking this medicine and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Allergy to penicillins, cephalosporins, imipenem

May prolong the neuromuscular blocking effect of vecuronium when used perioperatively. May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). May increase the risk of methotrexate toxicity. Probenecid may increase the peak serum level of piperacillin.

[SAFE] Consuming alcohol with Piperacillin does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Piperacillin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Piperacillin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Piperacillin should be used with caution in patients with kidney disease. Dose adjustment of Piperacillin may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Piperacillin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Piperacillin may not be needed in these patients. Please consult your doctor.

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