Protamin Sulphate

Protamin Sulphate is a medicine which is used in the treatment of heparin overdose. It neutralizes the anti-blood clotting effect of heparin and stops excessive bleeding. Protamin Sulphate is generally administered by a healthcare professional. You should not self administer this medicine. Inform your doctor if you have undergone heart surgery, have had a vasectomy, have diabetes, have received protamine insulin, or allergic to fish. Using of Protamin Sulphate can cause few side effects such as decreasing your blood pressure, slow heart rate, or reactions at the site of injection. It is important to monitor the clotting levels if you are receiving multiple doses or prolonged administration of protamine. Protamin Sulphate is used to counteract the anticoagulant effect of heparin and is used to stop bleeding in patients caused by heparin.

• Heparin overdose

Protamine sulfate, prepared from the sperm or mature testes of salmon or related species, is a heparin antagonist. It combines with heparin to form a stable inactive complex. Protamine sulfate is often used in the treatment of bleeding from severe heparin overdose and should not be used in minor overdose/bleeding as heparin withdrawal will usually correct itself within a few hr. For LMWH, protamine sulfate neutralises the anti-thrombin activity but only partly neutralises the anti-factor-Xa effect. When admin in the absence of heparin, protamine sulfate has an anticoagulant effect. Protamine is not useful for reversing the effects of oral anticoagulants.

Adult Dose: Intravenous Heparin overdosage Adult: Dosage depends on administered heparin dose, its route of admin, time elapsed since heparin admin, and blood coagulation studies. For heparin administered via IV inj: If only a few min have elapsed since admin, 1 mg for every 100 U of heparin administered; if 30-60 min have elapsed since admin, 0.5-0.75 mg for every 100 U of heparin; and if >2 hr have elapsed since admin, 0.25-0.375 mg for every 100 U of heparin. Doses to be given via inj at 8 hr has elapsed since admin, infuse 0.5 mg for every 1 mg of enoxaparin administered. For dalteparin: 1 mg for every 100 anti-Xa U of dalteparin administered. If aPTT remains prolonged 2-4 hr after the 1st infusion, a 2nd infusion may be given.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Protamin Sulphate, please consult your doctor.

Common: • Hypersensitivity • Decreased blood pressure • Slow heart rate

[SAFE] Protamin Sulphate does not usually affect your ability to drive.

Hypersensitivity.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Protamin Sulphate. Please consult your doctor.

[CONSULT YOUR DOCTOR] Protamin Sulphate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Protamin Sulphate is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Protamin Sulphate is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Protamin Sulphate may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Protamin Sulphate is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Protamin Sulphate may not be needed in these patients. Please consult your doctor.

I have very low hb so what should i take for You can take iron supplements like Ferrous sulphate Ferrous sulphate tablets toxicity There is no toxicity as such. Please be specific in what respect are you asking. For control of loose motions a doctor near by us recommended ondasetron syrup for vomiting, benegut for motions and an injection of amikacin sulphate injection IP for 3 days. now he advised satrogyl o 75 mg syrup. Dr need a final diagnosis or provisional diagnosis to suggest you investigations or medicine or give opinion. In present situation diagnosis cannot be done without taking in to consideration details of history and findings of clinical examination of patient. Advice given without doing clinical examination can be imperfect or some time harmful to patient. I m taking Beakasule and Folic acid should i take fefol z with these medcin instead of Ferrous sulphate kindly send pictures of affected area for better treatment. sir actuly my question is not regarding health .can you suggest me a medicine with iron chelate or ferric sulphate The law prohibits online prescriptions. And any medicine can be suggested only after a clinical check up Bee sting below middle finger, on palm yesterday. Swelling and redness today after approx 20 hours. No pain, only itching. Visit emergency for an injection at that place Instant reliefTake tab teczine 10mg -1tab at bedtime for itching