Ribociclib

Ribociclib is used in the treatment of metastatic breast cancer. It helps to slow down the growth of cancer cells and eventually kills them. Ribociclib is taken in a dose as advised by the doctor. The duration of treatment varies on the basis of your need and response to treatment. You may be asked for regular blood tests while taking this medication. It is better to inform doctor if you notice symptoms of infection like fever, chills and weakness. You should use effective contraception method to prevent pregnancy while taking this medicine It may cause dizziness, so avoid driving or any activity requiring mental focus until you know how it affects you. Neutropenia is a well-recognized adverse effect, in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection. However, this side effect disappears rapidly once you stop taking the medicine. Ribociclib is an anti-cancer medication. It works by blocking proteins (kinases) which are important for the growth and division of cells. This slows the growth of cancer cells and eventually kills them.

• Metastatic breast cancer

Ribociclib selectively inhibits cyclin-dependent kinases (CDK) 4 and 6 which are involved in cell proliferation. The interaction between cyclin D and CDK 4 and 6 is blocked, preventing the phosphorylation of tumour suppressor protein retinoblastoma and the progression of cell cycle from G1 into S phase thereby inhibiting cancer cell growth.

Adult Dose: Oral Hormone receptor positive, HER2-negative locally advanced carcinoma of breast, Hormone receptor positive, HER2-negative metastatic carcinoma of breast Adult: In combination with an aromatase inhibitor, or in combination with fulvestrant in postmenopausal women: 600 mg once daily preferably in the morning for 21 days followed by 7-days off to complete 28 days cycle. Pre/perimenopausal women should be treated with luteinising hormone-releasing hormone (LHRH) agonist. Dose reduction, dosing interruption, or discontinuation may be required according to individual safety or tolerability. Management of adverse reactions adjustment:1st reduction: 400 mg once daily; 2nd dose: 200 mg once daily; discontinue if dose reduction below 200 mg once daily is required. Hepatic impairment Mild (Child-Pugh A): No dose adjustment required Moderate-to-severe (Child-Pugh B or C): Reduce starting dose to 400 mg/day Renal Dose: Renal impairment Mild-to-moderate (CrCl ?30 mL/min): No dose adjustment necessary Severe (CrCl 15-30 mL/min): Decrease starting dose to 200 mg/day Only studied healthy subjects and noncancer subjects with severe renal impairment

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ribociclib may be taken with or without food, but it is better to take it at a fixed time.

Common: • Decreased white blood cell count • Nausea • Fatigue • Diarrhea • Hair loss • Constipation • Vomiting • Headache • Back pain • Anemia (low number of red blood cells)

[UNSAFE] Ribociclib may cause side effects which could affect your ability to drive. Some people may experience fatigue, dizziness, or vertigo during treatment with Ribociclib. If these happen you should be cautious when driving or using machines. Take it with food, preferably at the same time every day. If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up missed dose Use effective contraception method to prevent pregnancy while taking this medicine. It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you. You may be asked for regular blood tests while taking this medication. Inform your doctor if you notice symptoms of infection like fever, chills, and weakness. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Do not stop taking the medication without talking to your doctor first.

Pregnancy and lactation.

Increased risk of QT prolongation with antiarrhythmic drugs (e.g. amiodarone, disopyramide) and other drugs which are known to prolong QT interval (e.g. chloroquine, bepridil, pimozide, moxifloxacin, tamoxifen). May increase the plasma concentration and risk of toxicity with strong CYP3A4 inhibitors (e.g. clarithromycin, indinavir, itraconazole, nefazodone) and increase plasma concentration of CYP3A4 substrates (e.g. ergotamine, quinidine, cisapride). May decrease efficacy with CYP3A4 inducers (e.g. phenytoin, rifampicin, carbamazepine).

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Ribociclib. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ribociclib may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ribociclib is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

There is no data available. Please consult doctor before consuming the drug. There is no data available. Please consult doctor before consuming the drug.

BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details Breast cancer With lympnode and few skeletal metastatic What a bout ER PR AND HER2 Sir my brother have skin cancer can you do something for save his life ?? Treatment of cancer depends on whether it is localized or metastatic cancer Metastatic kidney cancer stage 4 Thanks for reaching out to meHe has progressive disease on sorafenib If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it's not a symptom of breast cancer. How to diagonise breast cancer? It should be diagnosed by mammogram and biopsy