Generic
Rosiglitazone
At a glance
Rosiglitazone — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Rosiglitazone is a medicine used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Rosiglitazone may be used by itself or along with other medicines. It may be taken with or without food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working. Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes. The most common side effects of taking this medicine include blurred vision, numbness and bone fracture. Please consult your doctor if these bother you or persist for a longer duration. You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease, thyroid disease or some hormonal conditions. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function. Rosiglitazone is an anti-diabetic medication. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.
Indications
• Type 2 diabetes mellitus
Mechanism of action
Lowers glucose by improving target cell response to insulin without increasing pancreatic cell secretion; activates nuclear peroxisome proliferator-activated receptor gamma, which influences the production of gene products involved in glucose and lipid metabolism
Dosage
Adult Dose: Type 2 Diabetes Mellitus Initial 4 mg PO qDay or divided q12hr If inadequate response afer 8-12 weeks, may increase dose to 8 mg PO qDay or divided q12hr Monitor: ALT at start of treatment, qMonth for 12 months then q3Months thereafter Dosage Modifications Active liver disease (ALT >2.5 x ULN): Do not inititate rosiglitazone Renal Dose: Renal impairment: No dosage adjustments required
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rosiglitazone may be taken with or without food, but it is better to take it at a fixed time.
Missed dose
If you miss a dose of Rosiglitazone, skip it and continue with your normal schedule. Do not double the dose.
Side effects
Common: • Blurred vision • Numbness • Bone fracture • Respiratory tract infection
Precautions & warnings
[SAFE] Rosiglitazone does not usually affect your ability to drive. Rosiglitazone has been withdrawn from the market due to an increased risk of heart attack and heart-related deaths.
Contraindications
Hypersensitivity to rosiglitazone Diabetic ketoacidosis Heart failure NYHA class III-IV Active liver disease: do not start rosiglitazone if ALT >2.5 x ULN
Food interactions
[UNSAFE] It is unsafe to consume alcohol with Rosiglitazone.
Use in pregnancy
[CONSULT YOUR DOCTOR] Rosiglitazone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[CONSULT YOUR DOCTOR] Information regarding the use of Rosiglitazone during breastfeeding is not available. Please consult your doctor.
Renal / hepatic impairment
[SAFE IF PRESCRIBED] Rosiglitazone is safe to use in patients with kidney disease. No dose adjustment of Rosiglitazone is recommended. [CAUTION] Rosiglitazone should be used with caution in patients with liver disease. Dose adjustment of Rosiglitazone may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.