Tenofovir Disoproxil Fumarate

Tenofovir Disoproxil Fumarate is used to treat HIV infection and chronic hepatitis B virus (HBV) infection in combination with other anti-HIV medicines. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Tenofovir Disoproxil Fumarate is not a cure for HIV/AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It may also be used to prevent HIV infection in some people at high risk. This medicine is best taken with food. It is used in combination with other anti-HIV medicines. Taking these medicines regularly at the right time greatly increases their effectiveness and reduces the chances of HIV becoming resistant to them. It is important not to miss doses and to keep taking them until your doctor tells you it is safe to stop. Common side effects of this medicine include nausea, vomiting, diarrhea, flatulence, trouble sleeping, headache, and rash. These are usually not serious but inform your doctor if they bother you or will not go away. It can also increase the risk of bone loss (osteoporosis) if you take it for a long time. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor. Some people may put on weight while taking medicines to treat HIV/AIDS. Before taking it, tell your doctor if you have any liver or kidney disease or bone problems. While taking it, you may need regular blood tests to check your blood counts, liver function, and kidney function. Since this medicine may cause dizziness or sleepiness, do not drive until you know how it affects you. Pregnant or breastfeeding mothers should consult their doctor before using this medicine. Do not have unprotected sex or share personal items like razors or toothbrushes, if you are HIV positive. Talk to your doctor about safe ways like condoms to prevent HIV transmission during sex. Tenofovir Disoproxil Fumarate is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.

• HIV infection • Chronic hepatitis B virus (HBV) infection

Tenofovir disoproxil fumarate, a diester prodrug of tenofovir, is a nucleotide reverse transcriptase inhibitor. After oral absorption, tenofovir disoproxil fumarate is rapidly converted to tenofovir and then undergo subsequent phosphorylation by cellular enzymes to the active tenofovir diphosphate, which inhibits the activity of HIV-1 reverse transcriptase.

Adult Dose: Oral Chronic hepatitis B; HIV infection (Indicated in combination with other antiretroviral agents for treatment of HIV-1 infection) Adult: 300 mg once daily. Child Dose: HIV Infection 2 years: 8 mg/kg PO qDay; not to exceed 300 mg/day Hepatitis B Infection 12 years; 12 years; >35 kg: 300 mg PO qDay Renal Dose: Renal impairment: Haemodialysis patients: 300 mg once every 7 days or after a cumulative total of 12 hr of dialysis. CrCl (ml/min) Dosage Recommendation 10-29 300 mg 72-96 hrly. 30-49 300 mg 48 hrly.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Tenofovir Disoproxil Fumarate is to be taken with food.

If you miss a dose of Tenofovir Disoproxil Fumarate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Rash • Weakness • Nausea • Stomach pain • Diarrhea

[UNSAFE] Tenofovir Disoproxil Fumarate may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Tenofovir Disoproxil Fumarate for the treatment of chronic hepatitis B virus (HBV) infection. In combination with other medicines, it is used for the treatment of HIV infections. Take it with food, as this increases the absorption of the medicine into the body. Tenofovir Disoproxil Fumarate may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. You may still develop infections or other illnesses associated with viral infection while taking this medication. You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them. During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.

Tenofovir is contraindicated in patients with previously demonstrated hypersensitivity to Tenofovir or any component of the product.

Decreased atazanavir concentration with tenofovir unless also co-administered with ritonavir. Increased serum concentration of tenofovir or co-administered drug if taken with drugs that are eliminated by active tubular secretion. Potentially Fatal: Increased risk of renal impairment with recent or concurrent use of nephrotoxic agents (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2); monitor renal function wkly if unavoidable. Increased didanosine levels and thereby increasing risk of pancreatitis and peripheral neuropathy, with a high treatment failure rate with concurrent use; avoid concurrent use.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Tenofovir Disoproxil Fumarate. Please consult your doctor.

[SAFE IF PRESCRIBED] Tenofovir Disoproxil Fumarate is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Tenofovir Disoproxil Fumarate is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Tenofovir Disoproxil Fumarate should be used with caution in patients with kidney disease. Dose adjustment of Tenofovir Disoproxil Fumarate may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Tenofovir Disoproxil Fumarate is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Tenofovir Disoproxil Fumarate may not be needed in these patients. Please consult your doctor.

I have HBV related chronic liver problem .Local urologist suggest me to take rapilif d 8 for urine block problem?Can i take that medicine with entavir for hepatitis b virus and cronic liver disease? Yes u can take it Suffering from Hepatitis B virus from last one week. Please suggest me. Pls consult a gastroenterologist How to treatment of HEPATITIS C VIRUS https://www.1mg.com/otc/himalaya-liv.-52-ds-tablet-otc135545One ?one tablet morning & evening after taking food , use at least 1-2 monthsUse this medicine along with your treatment What should be next course of action for me. Pls guide. I am about to be married and really scared. Dear PATIENT from 1mg. The reports shows positive Hepatitis B surface antigen which can be due to Hepatitis B infection. I suggest you should consult a Hepatologist/ Gatroenetrologist/ Physician for this. I M HBSAG ( HEPATITIS B POSITIVE) SO SIR any treatment treat my infection https://goo.gl/forms/5QhDt8ZurRhhcjvD2 Kindly fill the health information so that I can advice best products to you thanks Can a complete remedy medicine be expected for hepatitis b disease in coming years? This is my result is there any chance of me naturally become hepatitis b negative? IgM anti HBcAg, LFT ultrasound abdomen n HBV viral load(quantitative) HbeAg required to know whether it is chronic infection or carrier state Hepatitis b disise medicine's explain Hepatitis b disise medicine's explain https://www.1mg.com/otc/liv.52-hb-capsule-otc122387One ?one tablet morning & evening after taking food , use at least 1-2 monthsuse along with your treatment i have unprotected sex with my friend. Can I take any drugs now to prevent any STD/HIV infection Hello PATIENT to 1mg. There is some medicine for prophylactic but you need to see physician for prescription and better you check HIV status of both partner