Ticarcillin + Clavulanate

Ticarcillin + Clavulanate is a combination of two medicines used to treat various types of bacterial infections such as urinary tract infections, bone and joint infections, stomach infections and skin infections. It fights against the infection by killing the causative microorganisms. Ticarcillin + Clavulanate is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor's prescription. Common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions like pain, swelling or redness. Consult your doctor if these do not get better or persist for a longer duration of time. Before using the medicine, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally safe to use during pregnancy and breastfeeding if used under a doctor's supervision. Ticarcillin + Clavulanate is a combination of two medicines: Ticarcillin and Clavulanic Acid. Ticarcillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Ticarcillin against bacteria.

• Bacterial infections

Inhibits cell wall biosynthesis by binding to 1 of more penicillin binding proteins, which subsequently inhibits bacterial cell wall synthesis and has a bactericidal effect

Adult Dose: Septicemia Indicated for septicemia caused by beta-lactamase–producing isolates of Klebsiella spp, Escherichia coli, Staphylococcus aureus, or Pseudomonas aeruginosa 3.1 g IV q4-6hr Lower Respiratory Infections Indicated for lower respiratory infections caused by beta-lactamase–producing isolates of S. aureus, Haemophilus influenzae, or Klebsiella spp 3.1 g IV q4-6hr Bone & Joint Infections Indicated for bone and joint infections caused by beta-lactamase–producing isolates of S. aureus 3.1 g IV q4-6hr Skin & Skin Structure Infections Indicated for skin and skin structure infections caused by beta-lactamase–producing isolates of S. aureus, Klebsiella spp, or E. coli 3.1 g IV q4-6hr Urinary Tract Infections Indicated for UTIs (complicated or uncomplicated) caused by beta-lactamase–producing isolates of E. coli, Klebsiella spp, P. aeruginosa (or other Pseudomonas spp), Citrobacter spp, Enterobacter cloacae, Serratia marcescens, or S. aureus 3.1 g IV q4-6hr Intra-abdominal Infections Indicated for peritonitis caused by beta-lactamase–producing isolates of E. coli, K. pneumoniae, or Bacteroides fragilis group 3.1 g IV q4-6hr Gynecologic Infections Indicated for endometritis caused by beta-lactamase–producing isolates of Prevotella melaninogenicus, Enterobacter spp (including E. cloacae), E. coli, Klebsiella pneumoniae, S. aureus, or Staphylococcus epidermidis Dose based on ticarcillin component Moderate: 200 mg/kg/day IV divided q4-6hr Severe: 300 mg/kg/day IV divided q4hr Child Dose: Infections Dose based on ticarcillin component 3 months: 200-300 mg/kg/day IV divided q4-6hr; not to exceed 24 g/day >60 kg: As adults; 3.1 g IV q4-6hr Neonates (7 days old, 2 kg) OR (>7 days old, 1.2-2 kg): 225 mg/kg/day IV divided q8hr >7 days old, >2 kg: 300 mg/kg/day IV divided q8hr Cystic Fibrosis 300-600 mg/kg/day IV/IM divided q6hr; not to exceed 24 g/day Renal Dose: Renal Impairment Load: 3.1 g IV, THEN reduce maintenance dose based on creatinine clearance CrCl 30-60 mL/min: 2 g q4hr CrCl 10-30 mL/min: 2 g q8hr CrCl <10 mL/min: 2 g q12hr CrCl<10 mL/min & hepatic impairment: 2 g qDay Peritoneal dialysis: 3 g q12hr Hemodialysis: 2 g q12hr; supplement with 3 g after each dialysis session

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Diarrhea • Rash • Allergic reaction

[UNSAFE] Ticarcillin + Clavulanate may cause side effects which could affect your ability to drive. Ticarcillin + Clavulanate may cause side effects such as allergic reactions, dizziness or fits that may make you unfit to drive. You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect. Taking probiotics along with Ticarcillin + Clavulanate may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Take it with food and plenty of fluids to avoid an upset stomach. Stop taking Ticarcillin + Clavulanate and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it. Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Allergy to penicillins or other beta-lactam antibacterials (eg, cephalosporins, imipenem)

[SAFE] Consuming alcohol with Ticarcillin + Clavulanate does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Ticarcillin + Clavulanate is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Ticarcillin + Clavulanate is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CAUTION] Ticarcillin + Clavulanate should be used with caution in patients with kidney disease. Dose adjustment of Ticarcillin + Clavulanate may be needed. Please consult your doctor. [CAUTION] Ticarcillin + Clavulanate should be used with caution in patients with liver disease. Dose adjustment of Ticarcillin + Clavulanate may be needed. Please consult your doctor.

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