Generic
Urofollitropin
0 brands available in the market
At a glance
Urofollitropin — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Urofollitropin is used in the treatment of female infertility. It is used in women who have a problem with ovulation or are undergoing fertility treatments like in-vitro fertilization. Urofollitropin is given as an injection under the supervision of a doctor. Your doctor or nurse will help you to learn the exact method of self-administration. Your doctor will decide the right time to take the injection, so always follow your doctor's advice. The dose and how often you take it depends on what you are taking it for. You might be prescribed with certain other medicine as a part of your treatment. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include pain in abdomen, headache, bloating and hot flushes. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some side effects may mean you should inform your doctor immediately include dizziness, pelvic pain, faint, weight gain and trouble breathing. Before taking this medicine, tell your doctor if you have ever had vaginal bleeding, or had ovarian cyst or tumor of the uterus. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are already pregnant or breastfeeding. In females, Urofollitropin works by stimulating the release of estrogen which helps in the growth and development of the egg before release. It also helps to develop more follicles (eggs) in women undergoing assisted reproductive technology procedures.
Indications
• Female infertility
Mechanism of action
Urofollitropin, a gonadotrophin obtained from postmenopausal women's urine, possesses follicle-stimulating hormone (FSH) activity but almost no luteinising activity. Admin for 7-12 days results in follicular growth and maturation in females. When sufficient follicular maturation has occurred, human chorionic gonadotrophin should be given to induce ovulation.
Dosage
Adult Dose: Injection Polycystic ovarian syndrome; Female infertility Adult: Initially, 150 IU daily SC/IM for the first 5 days. Adjust subsequent dosing based on clinical monitoring (e.g. serum oestradiol levels and vaginal ultrasound). Dose adjustments should not be made more frequently than once every 2 days and be ?75-150 units per adjustment. Max dose: 450 units daily and max course of treatment: 12 days. Stop treatment when adequate response obtained as determined by oestrogen monitoring or ultrasonic visualisation of follicles. A single dose of chorionic gonadotrophin 5000 to 10 000 units is given to induce ovulation after 1-2 days. Urofollitropin treatment may be tried again in future cycles. Injection In vitro fertilisation procedures or other assisted conception techniques Adult: In conjunction with other agents: 150-225 units of FSH daily SC/IM from day 2 or 3 of menstrual cycle. Alternatively, begin therapy with clomifene citrate and continue with urofollitropin; or urofollitropin may be given after gonadorelin analogue is given to suppress gonadotrophin release. Continue treatment until an adequate response is obtained and admin 5000 to 10 000 units of chorionic gonadotrophin 1-2 days after final injection of urofollitropin. Oocyte retrieval is performed 34-35 hr later. Injection Male infertility Adult: In conjunction with chorionic gonadotrophin, 150 units of FSH SC/IM 3 times a wk, continue for at least 4 mth. Child Dose: Safety and efficacy not established
Administration
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Missed dose
If you miss a dose of Urofollitropin, please consult your doctor.
Side effects
Common: • Abdominal pain • Headache • Bloating • Pelvic pain • Abdominal cramp • Nausea • Respiratory disorder
Precautions & warnings
[SAFE] Urofollitropin does not usually affect your ability to drive. Your doctor may prescribe more than one medicine as part of a pregnancy plan. The injection is administered under the skin. Follow the recommended dosage and monitoring schedules to minimise the possibility of ovarian hyperstimulation. Inform your doctor immediately if you have severe pelvic pain, nausea, vomiting, diarrhea, sudden weight gain, trouble breathing, or decreased or no urination during treatment, as these could be symptoms of ovarian hyperstimulation syndrome (OHSS). Do not use Foligraf 150IU Injection if you are already pregnant or breastfeeding. Pregnancy following treatment with Foligraf 150IU Injection is more likely to result in a multiple pregnancy (twins or more) than if you had conceived naturally. Foligraf 150IU Injection stimulates the production of eggs in women having treatment for anovulatory infertility.
Contraindications
Pregnancy, ovarian cysts or enlargement not due to polycystic ovary syndrome, primary ovarian failure, organic intracranial lesion e.g. pituitary tumour, uncontrolled thyroid and adrenal dysfunction, presence of any cause of infertility other than anovulation, abnormal bleeding of undetermined origin.
Drug interactions
Increased risk of ovarian hyperstimulation syndrome with drugs with luteinising hormone activity.
Food interactions
[UNSAFE] It is unsafe to consume alcohol with Urofollitropin.
Use in pregnancy
[UNSAFE] Urofollitropin is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Use in lactation
[CONSULT YOUR DOCTOR] Information regarding the use of Urofollitropin during breastfeeding is not available. Please consult your doctor.
Renal / hepatic impairment
[CONSULT YOUR DOCTOR] There is limited information available on the use of Urofollitropin in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Urofollitropin in patients with liver disease. Please consult your doctor.
Common questions
infertility, since 2 years we are try to conceive to day doctor given injection persinal 150 HP Infertility is a complex issue and can be due to many reasons. A detailed evaluation of both partners is a must before you try out any treatment. hello,I need a suggestion. A female dog bited me one day before. I cleaned the wound & took tadebag injection. The dog was normal,it has no disease as it seems. The wounds are light,like tweaks,not deep.Is it necessary to take any other injection or anti rabies injection? Yes it is necessary Sperm infertility problem. It will be no infertility for sperm I could not get u My infertility in 5min my dots Plz my infertility problem cant understand ur problem Am trying to conceive I have pcos no follicle development so I taking obimet ovagain thyronorm 25 mg what can I do for next step. My doctor put fsh injection for follicle development for 3 days which 10th day of period ok that is fine, hope u are consulting infertility specialist and not gynaecologist Infertility problem. Taking treatment since may13. Did all test, iui, laparoscopy. said it's unexplained infertility. Hi PATIENT to 1mgd0ctors. Dorry to hear about your problem. Unexplained infertility is rising rapidly these days due to the high stress levels in our lives. I would suggest you continue taking treatment and I'm sure you will get a good news soon. All the best. Let me know if i can assist you in any way. Infertility due to vericocolee Please consult a surgeonI am a paediatrician Low sperm quality & infertility Take moosli Pak 1 spoon twice with milk, speman tablet 2 tablet twice with milk, chandraprabha vati 2 tablet twice