Vasopressin

Vasopressin is used in the treatment of diabetes insipidus, bleeding esophageal varices (bleeding from dilated veins in the food pipe leading to your stomach), and low blood pressure. Vasopressin is given by a healthcare professional. You should not self-administer this medicine at home. Your doctor will decide the dose and how often you should take them. Using this medicine can cause some common side effects such as headache, slow heart rate, high blood pressure, and low blood pressure. Let your doctor know if any of these side effects do not go away or get worse. Before using this medicine, inform your doctor if you have any problems with your heart, liver, or kidneys. You should also tell your doctor all the other medicines you are taking. This medicine is not recommended for children and adolescents. Vasopressin have the same structure as that of the natural hormone vasopressin. Vasopressin lowers the amount of urine and bleeding by constricting (narrowing) the blood vessels which, in turn, prevents the loss of water from the body.

• Bleeding esophageal varices • Diabetes insipidus • Low blood pressure

Vasopressin is a posterior pituitary hormone which may be synthetically prepared or extracted from animals. It exerts direct antidiuretic action on the kidneys by increasing tubular reabsorption of water. Vasopressin also acts by constricting the peripheral blood vessels and causes the smooth muscle of the intestine, gall bladder and urinary bladder to contract. Vasopressin is given parenterally or intranasally in the form of argipressin or lypressin. Argipressin is a synthetic type of vasopressin derived from most mammals (including man but excluding pig) while lypressin is vasopressin from pig.

Adult Dose: Intravenous Initial control of variceal bleeding Adult: 20 units in 100 ml of glucose 5% infused over 15 min. Parenteral Cranial diabetes insipidus Adult: 5-20 units SC/IM every 4 hr. Abdominal Distention Adult: 5 units IM initially; repeated q3-4hr PRN; may be increased to 10 units Hepatic impairment: Lower doses may be required to achieve response

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Vasopressin, skip it and continue with your normal schedule. Do not double the dose.

Common: • Decreased cardiac function • Decreased sodium level in blood • Ischemia • Slow heart rate

[SAFE] Vasopressin does not usually affect your ability to drive. Petresin 20IU Injection is given as an injection into veins under the supervision of a doctor. It makes you feel dizzy or lightheaded. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Tell your doctor if you are pregnant, planning to become pregnant or are breastfeeding.

Hypersensitivity. Vascular disease especially coronary artery disease; chronic nephritis (until reasonable blood-nitrogen conc attained).

Carbamazepine, chlorpropamide, clofibrate, urea, fludrocortisone and tricyclic antidepressants may potentiate the antidiuretic action of vasopressin. Demeclocycline, noradrenaline, lithium, heparin and alcohol may decrease antidiuretic action of vasopressin. Ganglionic blockers may increase sensitivity to the pressor effect of vasopressin. Increased risk of QT prolongation with dolasetron.

[UNSAFE] It is unsafe to consume alcohol with Vasopressin.

[CONSULT YOUR DOCTOR] Vasopressin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Vasopressin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Vasopressin in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Vasopressin in patients with liver disease. Please consult your doctor.

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