৳ 590/unit
Pack: ৳ 590
৳ 590/unit
Pack: ৳ 590
At a glance
Cholecalciferol (Vitamin D3) is a fat-soluble vitamin essential for calcium and phosphate homeostasis and bone mineralization . It is used as a dietary supplement when vitamin D intake is insufficient . It is used along with calcium to prevent and treat rickets, osteomalacia, and osteoporosis . It is especially important for people with limited sun exposure or dietary deficiency . In Bangladesh, it is available as film-coated tablets, capsules, chewable tablets, oral solution, and injection.
Indications
Osteoporosis: Prevention and treatment of bone loss in the elderly Rickets: Prevention and treatment of bone softening in children Osteomalacia: Bone softening in adults Hypoparathyroidism: Low calcium levels due to parathyroid hormone deficiency Vitamin D Deficiency: Low serum 25-hydroxyvitamin D levels Pre-eclampsia prevention during pregnancy – Vitamin D is essential for the growing infant Immune system support – Vitamin D plays a vital role in boosting immunity
Pharmacology
Vitamin D3 (cholecalciferol) is a prohormone that regulates calcium and phosphate balance in the body . It is first hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol) and then in the kidney to 1,25-dihydroxyvitamin D (calcitriol), the active form . Calcitriol increases intestinal absorption of calcium and phosphate, regulates bone resorption, and increases renal calcium reabsorption . It works by binding to vitamin D receptors (VDRs) present in virtually every cell and regulates the synthesis of hundreds of enzymes . As a fat-soluble vitamin, it has a half-life of about 50 days.
Dosage
Adult Dose: Oral /IM: Nutritional deficiency Colecalciferol (Vitamin D3) is recommended 5-10 mcg or 1-2ml (200-400 IU)/day Osteoporosis Prophylaxis and treatment >50 years: 800-1000 IU (20-25 mcg) PO once daily with calcium supplements. May also be given via IM inj. Hypoparathyroidism 50,000-200,000 IU (0.625-5 mg) PO once daily with calcium supplements. May also be given via IM inj. Child Dose: Nutritional Supplementation RDA 0-12 months: 400 IU (10 mcg) PO once daily 1-18 years: 600 IU (15 mcg) PO once daily Vitamin D-Resistant Rickets 12,000-500,000 IU (0.3-12.5 mg) PO once daily Familial Hypophosphatemia 40,000-80,000 IU (1-2 mg) PO once daily with phosphate supplements; may be reduced after stage of growth is complete
Side effects
Generally all nutritional supplements are considered to be safe and well tolerable. However, few side-effects can generally occur including hypercalcaemia syndrome or Calcium intoxication (depending on the severity and duration of hypercalcaemia), occasional acute symptoms include anorexia, headache, dry mouth, nausea, vomiting, abdominal pain or stomach ache and constipation with the administration of Colecaciferol.
Precautions & warnings
People with the following conditions should exercise caution when considering taking vitamin D supplements: High blood Calcium or Phosphorus level Heart problems Kidney disease Vitamin D must be taken with adequate amounts of both Calcium and Magnesium supplementation. When Calcium level is low (due to insufficient vitamin D and calcium intake), the body activates the parathyroid gland, which produces PTH (parathyroid hormone). This hormone kick starts vitamin D hormone production and assists removal of Calcium from the bones to be used in more important functions such as neutralizing body acidity. Lactation: Drug is distributed into breast milk; use with caution
Overdose effects
The most serious consequence of acute or chronic overdose is hypercalcemia (Vitamin D toxicity). Symptoms include nausea, vomiting, polyuria, anorexia, weakness, lethargy, thirst, and constipation. Chronic overdose may cause calcification of blood vessels and organs. Treatment includes discontinuation of Vitamin D and rehydration.
Storage conditions
Store in a cool, dry place at a temperature below 25°C, protected from light. Keep out of reach of children. Store the injection at 2°C–8°C.