osudhkosh
New
Company•Beacon Pharmaceuticals PLC

Nab-Xelpac

100mg/vialRx
Generic: Nanoparticle Albumin-Bound (NAB) Paclitaxel

৳ 25,000/unit

Pack: ৳ 25,000

InjectionInjection
Save to my medicines
Alert me on price drop

At a glance

Nanoparticle Albumin-Bound (NAB) Paclitaxel is a chemotherapy drug used for metastatic breast cancer, non-small cell lung cancer and pancreatic adenocarcinoma. It prevents depolymerization of cellular microtubules to stop cell division.

Indications
  • Metastatic breast cancer (after anthracycline failure)
  • Locally advanced or metastatic non-small cell lung cancer (with carboplatin)
  • Metastatic adenocarcinoma of the pancreas (with gemcitabine)
Pharmacology

NAB-Paclitaxel is an albumin-conjugated formulation that prevents depolymerization of cellular microtubules, resulting in inhibition of DNA, RNA and protein synthesis. Albumin improves paclitaxel delivery to tumor cells through SPARC protein.

Dosage

Breast Cancer: 260 mg/m² IV over 30 min, every 3 weeks

NSCLC: 100 mg/m² IV over 30 min on Days 1, 8, 15 of 21-day cycle + Carboplatin AUC 6

Pancreatic Cancer: 125 mg/m² IV over 30-40 min on Days 1, 8, 15 of 28-day cycle + Gemcitabine 1000 mg/m²

Side effects

Common Side Effects (>10%):

  • Alopecia (90%)
  • Neutropenia (80%)
  • Sensory neuropathy (71%)
  • Abnormal EKG (60%)
  • Asthenia (47%)
  • Myalgia/arthralgia (44%)
  • AST increased (39%)
  • Anemia (33%)
  • Nausea (30%)
  • Diarrhea (27%)
  • Dyspnea (12%)

Serious: Sepsis, pneumonitis, hypersensitivity reactions

Use in pregnancy

Use in Pregnancy: NAB-Paclitaxel is highly unsafe during pregnancy (Category D); definite evidence of severe fetal harm. Avoid pregnancy.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Causes myelosuppression; monitor CBC
  • Sensory neuropathy occurs frequently; may require dose reduction or treatment interruption
  • Biliary obstruction or stent are risk factors for severe sepsis
  • Increased toxicity in hepatic impairment
  • May cause fetal harm; avoid in pregnant women
  • Men should not father a child during treatment
Overdose effects

Overdose may cause myelosuppression and neuropathy; symptomatic treatment.

Storage conditions

Store below 25°C; protect from light; keep out of reach of children.

Nanoparticle Albumin-Bound (NAB) Paclitaxel — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.