Alemtuzumab

Alemtuzumab is used in the treatment of blood cancer (chronic lymphocytic leukemia) and multiple sclerosis (MS). It marks the cancer cells for destruction by the body's immune system. It also modulates the immune system to limit its attacks on the nervous system. Alemtuzumab is given under the supervision of doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Rash, headache, and insomnia are some common side effects of this medicine. This medicine may reduce the number of blood cells (white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Thus, inform your doctor immediately if you develop fever, chills, cough, mouth sores, or trouble breathing, and unusual bruising or bleeding, or blood in urine. You will be check regularly after giving the medication as it may cause fatal reaction such as chest pain, breathlessness, slow or irregular heartbeat. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Alemtuzumab is a monoclonal antibody. It flags the cancer cells for destruction by the body's immune system. It also modulates the immune system to limit its attacks on the nervous system.

• Blood cancer (Chronic lymphocytic leukemia) • Multiple sclerosis (MS)

Alemtuzumab is a recombinant humanised monoclonal antibody that binds to CD52, a nonmodulating antigen found on the surface of B and T lymphocytes, a majority of monocytes, macrophages, natural killer (NK) cells and subpopulation of granulocytes. Upon binding to CD52+, an antibody-dependent malignant cell lysis occurs.

Adult Dose: Intravenous B cell chronic lymphocytic leukaemia Adult: Initially, 3 mg daily via infusion over 2 hr (up to 8 hr in some patients). Repeat dose daily until tolerated then increase gradually to 10 mg daily. Dose escalation usually takes 3-7 days. Maintenance: 30 mg given 3 times wkly on alternate days, up to 12 wk. Modify dose according to haematological toxicity. Relapsing-remitting multiple sclerosis Adult: Initial treatment course: 12 mg daily via infusion over 4 hr for 5 consecutive days to a total dose of 60 mg. 2nd treatment course: 12 mg daily via infusion over 4 hr for 3 consecutive days to a total dose of 36 mg given 12 mth after the initial treatment course.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Alemtuzumab, please consult your doctor.

Common: • Rash • Headache • Insomnia (difficulty in sleeping) • Nausea • Upper respiratory tract infection • Decreased white blood cell count • Fatigue • Fever • Itching • Flushing (sense of warmth in the face, ears, neck and trunk) • Hives • Decreased white blood cell count (lymphocytes)

[UNSAFE] Alemtuzumab may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Alemtuzumab is given as an injection into the veins under the supervision of a doctor.

Active systemic infection or underlying immunodeficiency.

May reduce efficacy of inactivated vaccines. Not recommended for use w/in 3 wk of other chemotherapy drugs. Live viral vaccines should not be used for at least 12 mth after alemtuzumab therapy.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Alemtuzumab. Please consult your doctor.

[CONSULT YOUR DOCTOR] Alemtuzumab may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Alemtuzumab is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Alemtuzumab in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Alemtuzumab in patients with liver disease. Please consult your doctor.

Multiple sclerosis treatment and medicine. many availabe; show to a neurologist Multiple sclerosis diagnosed with 2 year back what u want to know Multiple sclerosis need lost cost medicine this forum is for patients to get second opinion about their diseases. She is suffering from chronic myeloid leukemia Hi Kindly consult to Ayurvedic doctor at your local city area , face to face consult is needed. Hey,this is PATIENT I'm patient of multiple sclerosis. Doctor suggest me to take injection relibeta beta-a. I'm taking this injection since August 2016. Is any other advise to cure. Give me suggestion regarding this. medicine ok ; stronger medicine in selected cases; show to neuroi and discuss My friend has multiple sclerosis is there any cure for her in ayurvedic Yah, but case has to be seen in person Multiple sceloris_glatira injection 6 months can cure ? there is no curative trt in Ms; this drug lowers rate of progresion and lowers risk of disability Suffering from multiple siclorises (MS) want treatment for this problem nd feeling too much weakness in body always drowzy Some medicine can help They are costly Show to a neurologist