Flecainide

Flecainide is a medicine used to treat certain types of arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. This helps to maintain a regular and steady heartbeat. Flecainide should be taken regularly as advised by the doctor. You should take it on an empty stomach and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. Side effects like dizziness, blurred vision, headache, weakness, edema (swelling), and irregular heart rate may be seen in some patients. Your doctor may advise for regular monitoring of blood sugar levels and kidney function while you are taking this medicine. This medicine may not be suitable for some people. You must inform the doctor if you are suffering from any heart, liver or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Flecainide is an anti-arrhythmic medication. It works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to a normal rhythm.

• Arrhythmia

Flecainide, an amide anaesthetic, belongs to Class Ic antiarrhythmic agents. It inhibits the transmembrane influx of extracellular Na ions via fast channels on cardiac tissues resulting to a decrease in rate of depolarisation of the action potential, prolonging the PR and QRS intervals. At high concentrations, it exerts inhibitory effects on slow Ca channels, accompanied by moderate negative inotropic effect.

Adult Dose: Oral Arrhythmias (Prevention) PSVT and paroxysmal atrial fibrillation 50 mg PO BID; may increase by 50 mg every 4 days; do not exceed 300 mg/day Sustained VT 100 mg PO BID initiated in hospital; may increase by 50 mg every 4 days; do not exceed 400 mg/day Hepatic impairment Use only if benefits outweigh risk; monitor plasma levels regularly; reduce dose as necessary Child Dose: Arrhythmias 6 months: 100 mg/m²/day PO divided q8-12hr Not to exceed 200 mg/m²/day Renal Dose: Renal impairment Severe (25 mL/min: 100 mg PO BID

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Flecainide is to be taken empty stomach.

If you miss a dose of Flecainide, skip it and continue with your normal schedule. Do not double the dose.

Common: • Dizziness • Blurred vision • Arrhythmia (irregular heartbeats) • Headache • Palpitations • Double vision • Weakness • Fatigue • Fever • Edema (swelling)

[UNSAFE] Flecainide may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It may cause dizziness. Do not drive or perform activities require mental focus until you know how it affects you. Do not start any medicine including prescription or over-the-counter medicines without informing your doctor, as they may alter Flecainide levels in your body. Your doctor may get blood tests done to check your sodium and potassium levels, kidney function, and lung function before starting treatment with this medicine. Your doctor may regularly monitor blood sugar level while taking this medicine. Inform your doctor if you experience slow or fast heart rate, chest pain, shortness of breath. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Do not stop taking medication suddenly without talking to your doctor.

Pre-existing 2nd- or 3rd-degree AV block w/o pacemaker, right bundle branch block associated w/ left hemiblock w/o pacemaker, cardiogenic shock, heart failure, history of MI, known Brugada syndrome.

Increased incidence of cardiac arrhythmias w/ other antiarrhythmics or arrhythmogenic drugs. Additive negative inotropic effects w/ Class II antiarrhythmics. Increased plasma conc w/ amiodarone, cimetidine quinidine, and ritonavir. Hypokalaemia may result w/ diuretics, corticosteroids, and laxatives.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Flecainide. Please consult your doctor.

[CONSULT YOUR DOCTOR] Flecainide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Flecainide is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Flecainide should be used with caution in patients with kidney disease. Dose adjustment of Flecainide may be needed. Please consult your doctor. [CAUTION] Flecainide should be used with caution in patients with liver disease. Dose adjustment of Flecainide may be needed. Please consult your doctor.

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