Omeprazole + Domperidone

Omeprazole + Domperidone is a prescription medicine used to treat gastroesophageal reflux disease (Acid reflux) and peptic ulcer disease by relieving the symptoms such as heartburn, stomach pain, or irritation. It also neutralizes the acid in the stomach and promotes easy passage of gas to reduce stomach discomfort. Omeprazole + Domperidone is taken without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine. Most common side effects are diarrhea, stomach pain, dryness in mouth, headache, and flatulence. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any side effects. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your dizziness. Lifestyle modifications like having cold milk and avoiding hot tea, coffee, spicy food or chocolate can help you to get better results. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have liver diseases so that your doctor can prescribe a suitable dose for you. Omeprazole + Domperidone is a combination of two medicines: Domperidone and Omeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Omeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and heartburn.

• Gastroesophageal reflux disease (Acid reflux) • Peptic ulcer disease

Domperidone is a peripheral dopamine D2-receptor antagonist, which regulates the motility of gastric and small intestinal smooth muscle. It increases the duration of antral and duodenal contractions and also LES resting pressure, thus stimulating gastric emptying and is also effective in relief of symptoms of reflux esophagitis. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone. Omeprazole inhibits the secretion of gastric acid by irreversibly blocking the enzyme system of H+/K+ ATPase of the gastric parietal cell. It is activated at an acidic pH to a sulphenamide derivative that binds irreversibly to H+/K+ ATPase, an enzyme system found at the secretory surface of parietal cells. It thereby inhibits the final transport of hydrogen ions (via exchange with K ions) into the gastric lumen.

Adult Dose: Oral Dyspepsia, Gastro-oesophageal reflux disease Adult: 1 cap bid or as directed by the physician.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Omeprazole + Domperidone is to be taken empty stomach.

Common: • Diarrhea • Stomach pain • Dryness in mouth • Headache • Flatulence

[UNSAFE] Omeprazole + Domperidone may cause side effects which could affect your ability to drive. Omeprazole + Domperidone may cause dizziness and visual disturbances. This may affect your driving ability. You have been prescribed Aciloc RD 20 Tablet for the treatment of acidity and heartburn. Take it one hour before the meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention. Long-term use can cause weak bones and deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.

Pregnancy. Domperidone is contraindicated in conditions associated with rise in prolactin level. Omeprazole is contraindicated in hypersensitive patients.

Anticholinergics may antagonize beneficial effects of domperidone in reflux oesophagitis and dyspepsia. Decreased bioavailability of domperidone after prior admin of cimetidine or Na bicarbonate. Delayed elimination of diazepam, phenytoin and warfarin with omeprazole.

[CAUTION] Caution is advised when consuming alcohol with Omeprazole + Domperidone. Please consult your doctor.

[CONSULT YOUR DOCTOR] Omeprazole + Domperidone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Omeprazole + Domperidone is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Omeprazole + Domperidone should be used with caution in patients with kidney disease. Dose adjustment of Omeprazole + Domperidone may be needed. Please consult your doctor. [CAUTION] Omeprazole + Domperidone should be used with caution in patients with liver disease. Dose adjustment of Omeprazole + Domperidone may be needed. Please consult your doctor. Use of Omeprazole + Domperidone is not recommended in patients with moderate and severe liver disease.