Quinidine

Quinidine is a medicine used to treat arrhythmia (abnormal heart rhythm). It restores normal heart rhythm by blocking abnormal electrical signals in the heart. This helps to maintain a regular and steady heartbeat. Quinidine should be taken regularly as advised by the doctor. You should take it with food and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor as this can worsen your condition. Regular follow-up with your doctor is advised while using this medicine. It may cause side effects like nausea, vomiting, low blood pressure, ringing in ear, headache and blurred vision. Your doctor may advise for regular monitoring of kidney function and blood sugar levels while you are taking this medicine. This medicine may not be suitable for some people. You must inform doctor if you are suffering from any liver or kidney disease. Also let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Quinidine is an anti-arrhythmic medication. It works by blocking abnormal electrical signals in the heart to correct irregular heartbeat to a normal rhythm.

• Arrhythmia

Quinidine is a Class IA (membrane stabilizing) antiarrhythmic w/ antimuscarinic and α-adrenoceptor blocking properties. It depresses phase O of the action potential, reduces Na influx during depolarisation and K efflux in repolarisation, thereby decreasing myocardial excitability and conduction velocity, and myocardial contractility. It also decreases Ca transport across cell membrane.

Adult Dose: Arrhythmias Quinidine Sulfate Test Dose: 200 mg PO quinidine sulfate several hr before full dosage Atrial fibrillation: 300-400 mg PO q6hr PSVT: 400-600 mg PO q2-3hr until paroxysm terminated Atrial/Ventricular Premature Contractions: 200-300 mg PO q6-8hr Maint: 200-400 mg PO q6-8hr or 600 mg of SR PO q8-12hr No more than 3-4 g/day Quinidine Gluconate 324-660 mg PO q8-12hr Maintenance: 648 mg PO q12hr OR 324-660 mg PO q8hr PSVT: 400 - 600 mg PO q2-3hr until paroxysm is terminated IV: Usual <5 mg/kg (but may need up to 10 mg/kg) at 0.25 mg/kg/min Malaria Quinidine gluconate for injection is no longer available in the U.S. Quinidine Gluconate Regimen I Load: 24 mg/kg diluted in 250 mL NS IV infusion over 4 hours Maintenance: Follow by 12 mg/kg IV infusion over 4 hours q8hr beginning 8 hr after initiation of loading dose except in patients able to swallow the same doses of quinidine are administered using 300 mg quinidine sulfate tablets Regimen II Load: 10 mg/kg diluted in 5 mL/kg NS IV over 1-2 hr Maintenance: Follow by 0.02 mg/kg/min continuous IV infusion; in patients able to swallow oral quinine is administered every 8 hr to give as much quinine as patient received in quinidine q8hr PO regimen: 300 mg quinidine or 650 mg quinine PO q8hr for 3 days (Africa and South America) or 7 days (Southeast Asia) or until parasitemia is reduced to 1% Child Dose: Arrhythmias Quinidine sulfate: 30 mg/kg/day or 900 mg/m²/day PO given in 5 divided doses OR 15-60 mg/kg/day divided q6hr PO Test Dose: 2 mg/kg PO quinidine sulfate; test dose not to exceed 200 mg Malaria Quinidine gluconate for injection is no longer available in the U.S. Load: 10 mg/kg diluted in 5 mL/kg NS IV over 1-2 hr Maintenance: Follow by 0.02 mg/kg/min continuous IV infusion; in patients able to swallow oral quinine is administered every 8 hr to give as much quinine as patient received in quinidine q8hr PO regimen: 650 mg quinine PO q8hr for 3 days (Africa and South America) or 7 days (Southeast Asia) or until parasitemia is reduced to 1% Renal Dose: Renal impairment CrCl 10 L/min: Dose adjustment not necessary

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Quinidine is to be taken with food.

If you miss a dose of Quinidine, skip it and continue with your normal schedule. Do not double the dose.

Common: • Nausea • Vomiting • Ringing in ear • Abdominal pain • Orthostatic hypotension (sudden lowering of blood pressure on standing) • Headache • Hypoglycemia (low blood glucose level) • Dysphoria (state of generalized dissatisfaction with life) • Diarrhea • Visual impairment • Deafness

[CONSULT YOUR DOCTOR] It is not known whether Quinidine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. It may cause dizziness. Do not drive or perform activities require mental focus until you know how it affects you. Do not start any medicine including prescription or over-the-counter medicines without informing your doctor, as they may alter Quinidine levels in your body. Your doctor may get blood tests done to check your sodium and potassium levels, kidney function, and lung function before starting treatment with this medicine. Your doctor may regularly monitor blood sugar level while taking this medicine. Inform your doctor if you experience slow or fast heart rate, chest pain, shortness of breath. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Do not stop taking medication suddenly without talking to your doctor.

Complete AV block (w/o functional pacemaker), myasthenia gravis, history of quinidine/quinine-associated thrombocytopenic purpura.

Reduced renal clearance w/ drugs that alkalinise the urine (e.g. carbonic-anhydrase inhibitors, Na bicarbonate, thiazide diuretics). Increased plasma levels w/ cimetidine, amiodarone, ketoconazole, verapamil. Decreased plasma levels w/ nifedipine. Increased hepatic elimination w/ rifampicin, phenytoin, phenobarbital. Potentiates the action of depolarising (e.g. suxamethonium) and nondepolarising (e.g. pancuronium) neuromuscular blocking agents, and warfarin. May increase plasma levels of digoxin, haloperidol, procainamide.

[UNSAFE] Quinidine may cause excessive drowsiness with alcohol.

[CONSULT YOUR DOCTOR] Quinidine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Quinidine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Quinidine should be used with caution in patients with severe kidney disease. Dose adjustment of Quinidine may be needed. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Quinidine in patients with liver disease. Please consult your doctor.

Taking 100mg tablet in morning Which tablet for what Suhagra 100mg tablet have any side effect? all pills have side effects. if ur heart is fine its ok and for others google it. Hello Doctor, What is use of eating caverta 100mg tablet? Hello Vijaya it will increase sex time and long holding Having difficulty in getting full erections. I take concor 1.25 and roseday 10 as prescribed for arrhythmia. What can be prescribed to me ? Treatment for erectile dysfunction: 1.stop smoking and alcohol 2.join a gym and reduce weight. Do weight lifting exercises. 3.tablet sildenafil or viagra 1 tablet 1 hour before sexual activity. 4.Get tested so that u don?t have any of the following causes: 1.heart diseases 2. diabetes 3.neurological problems 4.hormonal problems 5.drug side effects I have been diagnosed with chlamydia pneumoniae Can u help me with the medication take tablet microdox dt 100mg 1 bd for 10 days The ecg report is Sinus Arrhythmia and short PR interval. What does it mean? Normal for d age I feel erectile dysfunction and loss of libidos for some time.I am a diabetic for the last 16 years,( mostly in control by oral medicine) age 48. Any treatment? keep ur fasting sugars till 100mg/dl.take tablet dejac t1 hr befr sex The ecg report is Sinus Arrhythmia and Short PR interval. What does it mean? What does it mean? Normal for 5 yrs