Ritonavir + Lopinavir

Ritonavir + Lopinavir is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome). Ritonavir + Lopinavir restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine should be taken with food for better efficacy. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine. The most common side effects of this medicine are diarrhea, nausea, vomiting, and increased blood fat levels (hypertriglyceridemia and hypercholesterolemia). These side effects are generally temporary, but if they persist or become serious inform your doctor. Drinking plenty of fluid can help you to cope up with these side effects, so stay hydrated. In addition to that, avoid alcohol consumption as it may increase the intensity of the side effects. Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular laboratory tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse. Ritonavir + Lopinavir is a combination of two anti-HIV medicines: Ritonavir and Lopinavir. They work by interfering with an enzyme (protease), which is required by HIV-infected cells to make new viruses. This stops the production of new viruses.

• HIV infection

Lopinavir inhibits HIV protease, causing the enzyme incapable of processing the polyprotein precursor. This leads to the production of non-infectious and immature HIV particles. Ritonavir, a selectively competitive reversible inhibitor of HIV protease, interferes with the formation of essential proteins and enzymes. After which, the formation of immature and non-infectious viruses follows. It also interferes with the production of infectious HIV and limits further infectious spread of the virus.

Adult Dose: HIV-1 Infection 400 mg/100 mg PO q12hr, OR 800 mg/200 mg PO qDay in patients with <3 lopinavir resistance-associated substitutions Once-daily dosing is only recommended for protease inhibitor-naïve patients and not for pregnant women or coadministration with efavirenz, nevirapine, fosamprenavir, nelfinavir, carbamazepine, phenytoin, or phenobarbital Coadministration with efavirenz, nevirapine, fosamprenavir, or nelfinavir Protease inhibitor naive or experienced 500 mg/125 mg PO q12hr (ie, 2 x 200 mg/50 mg + 100 mg/25 mg), OR Oral solution or capsules: 533 mg/133 mg PO q12hr (ie, ~6.5 mL q12hr) Child Dose: HIV-1 Infection Do not use once-daily dosing in children or adolescents (administer q12hr) 40 kg: As adults; 400 mg/100 mg PO q12hr Oral tablets: 6 months-18 years (not receiving concomitant efavirenz, nevirapine, fosamprenavir, or nelfinavir) 15-20 kg or 0.6 to 20-30 kg or 0.8 to 30-45 kg or 1.2 to 45 kg or >1.7 m²: 400-600 mg/100-150 mg PO q12hr (use higher dose for treatment-experienced patients) 6 months-18 years (coadministered with efavirenz, nevirapine, fosamprenavir, or nelfinavir) 300 mg/75 mg (LPV/r)/m²/dose PO bid, not to exceed 400 mg/dose of lopinavir FDA-approved dose: 500 mg/125 mg LPV/r PO bid, administer as combination of 2 tab of 200/50 mg LPV/r and 1 tab of 100 mg/25 mg LPV/r Most NIH Panel members recommend 600 mg/150 mg LPV/r PO bid

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ritonavir + Lopinavir is to be taken with food.

Common: • Taste change • Headache • Nausea • Vomiting • Diarrhea • Stomach pain • Increased liver enzymes • Increased blood lipid level • Peripheral neuropathy (tingling and numbness of feet and hand)

[CONSULT YOUR DOCTOR] It is not known whether Ritonavir + Lopinavir alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Ritonavir + Lopinavir is a combination medicine which slows down or stops the progression of HIV infection in the body. Take it with food, preferably at the same time each day. Skipping doses increases the risk of treatment failure. Make sure that you take all your doses at the correct time. It may cause weight gain and weakening of your bones. Eat healthy, exercise regularly and take calcium and vitamin D supplements as suggested by your doctor. It may cause dizziness and sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you. Your doctor may monitor your kidney and liver functions regularly. Inform your doctor if you develop symptoms such as abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin. Do not stop taking Ritonavir + Lopinavir without your doctor's advice.

Hypersensitivity. Avoid concomitant use with ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), cisapride, pimozide, and sedatives (midazolam, triazolam).

Ritonvir ....Decreased plasma conc with phenobarbital, carbamazepine, dexamethasone, phenytoin, rifabutin and rifampicn. Increased plasma conc of certain drugs highly metabolized by CYP3A. May increase serum levels of sildenafil. Potentially Fatal: Avoid concurrent admin of oral solution (contains alcohol) with disulfiram or metronidazole. Increased risk of myopathy when used with simvastatin or lovastatin. Concurrent use with alfuzosin may lead to serious hypotension. Increased risk of cardiac arrhythmias when used with amiodarone, cisapride, propafenone, quinidine, flecainide and pimozide. Risk of acute ergot toxicity when used with ergot derivatives. Increased risk of serious adverse reactions when used with midazolam or triazolam. Lopinavir....Most interactions reported with lopinavir are due to its combination with the potent inhibitor of CYP3A4 ritonavir. Lopinavir levels may be decreased by CYP3A4 inducers such as efavirenz, nevirapine, amprenavir, nelfinavir, rifampicin, phenytoin. Lopinavir level are increased by CYP3A4 inhibitors such as valproate and rifabutin. Potentially Fatal: Severe myelosuppression reported with paclitaxel.

[CAUTION] Caution is advised when consuming alcohol with Ritonavir + Lopinavir. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ritonavir + Lopinavir may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Ritonavir + Lopinavir is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[SAFE IF PRESCRIBED] Ritonavir + Lopinavir is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Ritonavir + Lopinavir may not be needed in these patients. Please consult your doctor. [CAUTION] Ritonavir + Lopinavir should be used with caution in patients with liver disease. Dose adjustment of Ritonavir + Lopinavir may be needed. Please consult your doctor.

i have unprotected sex with my friend. Can I take any drugs now to prevent any STD/HIV infection Hello PATIENT to 1mg. There is some medicine for prophylactic but you need to see physician for prescription and better you check HIV status of both partner hello, one of my frnd suffering with hiv infection from last 2yrs her cd4 is more than 470 and viral load is zero undetectable now she is using art medicines i have doubt that can we have to use art medicine in the whole life or can we stop it once we get viral load zero You still need to be on ART even if the viral load is undetectable I am suffering from HIV 1 infection. Take medicines then and monitor ur cd4 count periodically What are the symptoms of HIV infection Fever, sourthroat, loosemotions, rashes on body, enlarged lymphnodes Plz suggest tablet for throughte infection (oil infection) Visit ent specialist for complete examination as it can be tonsillitis Plz suggest tablet for urine infection Pls show your urine R/m & utine culture reports first. when symptoms of hiv can be seen.what is the test name for digonosefir hiv Hi Kindly consult to your nearest hospital I don&#x27;t have hiv but what is symptoms Tell me symptoms of hiv List of symptoms is big as many organ system can be involved in HIV. It is beyond the scope of this form