Dacarbazine

Dacarbazine is used in the treatment of cancers of lymphatic system and malignant melanoma (a type of skin cancer). It may be also used to treat other conditions, as determined by the doctor. Dacarbazine is given as an injection into a vein by the healthcare professional, but better if injected at the same time every day. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine nausea, vomiting, injection site pain, and decreased white blood cell count. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Inform your doctor if you notice unusual bleeding or bruising, lack of energy, loss of appetite, and yellowing of eyes. Your doctor will advise you regular blood tests to check for these. Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Dacarbazine is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

• Malignant melanoma • Hodgkin’s disease

The exact mechanism of action is still unclear but it appears to form methylcarbonium ions that attack nucleophilic groups by attaching to the 7-position of guanine on DNA. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis.

Adult Dose: Intravenous Metastatic melanoma Adult: 2-4.5 mg/kg daily for 10 days, repeat at 4-wk intervals or 200-250 mg/m2 BSA daily for 5 days, repeat at 3-wk intervals or 850 mg/m2 BSA by infusion, repeat at 3-wk intervals. Hodgkin's disease Adult: 150 mg/m2 BSA daily for 5 days, repeat every 4 wk or 375 mg/m2 BSA every 15 days in combination with other agents. Soft tissue sarcoma Adult: 250 mg/m2 BSA daily for 5 days repeated every 3 wk. Usually given with doxorubicin. Child Dose: Hodgkin's Disease With other antineoplastics, eg ABVD Dosage dependent on protocol150 mg/m² IV qDay for 5 days, repeat q4Weeks OR 375 mg/m² IV on Day 1; repeat every 15 Days

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Dacarbazine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Vomiting • Injection site pain • Decreased white blood cell count • Loss of appetite

[UNSAFE] Dacarbazine may cause side effects which could affect your ability to drive. Dacarbazine may influence the ability to drive because of its central nervous system side effects. Dacarbazine is given as an injection into veins under the supervision of a doctor.

Bone marrow suppression; hypersensitivity.

Impairs immune response to vaccines; possible infection after admin of live vaccines. Effect increased by CYP1A2 inhibitors e.g. amiodarone, ciprofloxacin, fluvoxamine, ketoconazole, lomefloxacin, ofloxacin and rofecoxib. Effect decreased by CYP1A2 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital and rifampicin.

[CAUTION] Caution is advised when consuming alcohol with Dacarbazine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Dacarbazine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Dacarbazine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Dacarbazine should be used with caution in patients with kidney disease. Dose adjustment of Dacarbazine may be needed. Please consult your doctor. [CAUTION] Dacarbazine should be used with caution in patients with liver disease. Dose adjustment of Dacarbazine may be needed. Please consult your doctor.

Brain star tablet for which disice For neuroleptic malignant syndrome Aprus disease it is on last finger nail Please suggest medicine for the disease You may take Antim crud 200, 4 drops in half cup water thrice daily for 15 days This type of baldness is appearing after every 2 -3 month.please suggest any remedy. is this indication of any serious disease Best treatment is intralesional injection of steroid I have a problem of keloids please suggest me which medicine I vl take n which injection I will use on that skin disease Visit a dermatologist for intralesional injection if any one detect with melanoma is it sure that he/she gonna die after 5 or 10 year No if melanoma is localized it can be removed by surgery (1)i have lypoma bubbles in mybody at different parts, why and what reason for lypoma. Will it any possibility to become cancer? (2)Always i feel laziness no active in the body why so? They are non malignant and can be removed surgically Docter prescribe the injection avogest 200 injection .my question is that why its use in pragenecy .my 3 month is completed It helps in stabilising pregnancy. If you have no pain or history of abortions,it can omitted. I am 7month pregnant, heart rate are increases near 200, which injection safe Hi PATIENT fetus heart rate upto 160 is normal at 7 months. However sometimes during movements it can intermittently go upto 180 to 190. 200 is definitely very high. However if it is continuously high, it's a cause for concern otherwise notPlease take lots and lots of water to so that baby's has a good supply of nutrients. If your water intake is low it can cause baby problems.However there is no medication to lower baby's heart rate, but you must keep a track on it.