Dacarzin200mg/vial
Rx- Generic:
- Dacarbazine
- Company:
- Beacon Pharmaceuticals PLC
- Dosage form:
- Injection
- Pack size:
- Injection
৳ 1,000/unit
Pack: ৳ 1,000
At a glance
Dacarbazine is an antineoplastic agent used for the treatment of metastatic malignant melanoma and Hodgkin's disease as second-line therapy.
Indications
- Metastatic malignant melanoma
- Hodgkin's disease (second-line therapy)
- Soft tissue sarcoma
Dosage
Adult - Malignant Melanoma: 2-4.5 mg/kg/day IV for 10 days, repeat at 4-week intervals; OR 250 mg/m²/day IV for 5 days, repeat at 3-week intervals; OR 850 mg/m² IV infusion, repeat at 3-week intervals.
Adult - Hodgkin's Disease: 150 mg/m²/day IV for 5 days, repeat every 4 weeks; OR 375 mg/m² IV on Day 1, repeat every 15 days (in combination with other agents).
Adult - Soft Tissue Sarcoma: 250 mg/m²/day IV for 5 days, repeated every 3 weeks (usually given with doxorubicin).
Child - Hodgkin's Disease: 150 mg/m² IV daily for 5 days, repeat every 4 weeks; OR 375 mg/m² IV on Day 1, repeat every 15 days (as part of ABVD regimen).
Side effects
Common Side Effects:
- Nausea and vomiting (>90% of patients)
- Injection site pain
- Decreased white blood cell count
- Loss of appetite
- Diarrhea (rare)
Serious Side Effects:
- Bone marrow suppression
- Tissue damage (extravasation)
- Hypersensitivity reactions
Precautions & warnings
- May affect your ability to drive due to CNS side effects.
- Extravasation during intravenous administration may result in tissue damage and severe pain.
- Adequate laboratory study capability must be available during treatment.
- Avoid during pregnancy and lactation.
- Effective contraception by both males and females is important.