Generic
Latanoprostene Bunod
1 brands available in the market
At a glance
Latanoprostene Bunod 0.024% ophthalmic solution is indicated for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It increases aqueous humor outflow through both the trabecular meshwork and uveoscleral routes.
Description
Latanoprostene Bunod is a prostaglandin analog that is thought to lower intraocular pressure by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. IOP is a major modifiable risk factor for glaucoma progression; reduction of IOP reduces the risk of glaucomatous visual field loss.
Indications
- Open-angle glaucoma
- Ocular hypertension
Therapeutic class
Miotics and Glaucoma Drugs
Pharmacological class
Prostaglandin Analog
Pharmacology
Latanoprostene Bunod lowers IOP by increasing aqueous humor outflow through both the trabecular meshwork and uveoscleral routes.
Mechanism of action
Increases aqueous humor outflow to reduce intraocular pressure.
Dosage
Adult Dose:
- 1 drop in the conjunctival sac of the affected eye(s) once daily in the evening
- Do not use more than once daily (more frequent use may lessen the IOP-lowering effect)
- Allow 5 minutes interval with other topical ophthalmic drugs
Administration
- For ophthalmic use only
- Remove contact lenses before application (contains benzalkonium chloride)
- Lenses may be reinserted 15 minutes after administration
Missed dose
Not generally applicable (regular daily use); consult doctor if needed.
Side effects
Side Effects:
- Pigmentation changes (iris and periorbital tissue) - may be permanent
- Eyelash changes (increased length, thickness, number) - reversible
- Intraocular inflammation (iritis/uveitis) - caution
- Macular edema (including cystoid macular edema)
- Bacterial keratitis - associated with contamination of multiple-dose containers
Precautions & warnings
- Pigmentation changes: Increased iris pigmentation (permanent); periorbital tissue darkening (reversible)
- Caution with history of intraocular inflammation; do not use with active inflammation
- Caution in aphakic, pseudophakic (with torn posterior capsule), or patients with risk factors for macular edema
- Do not use with contact lenses (contains benzalkonium chloride)
Contraindications
- Hypersensitivity to any component of this preparation
Drug interactions
No significant drug interactions known (topical ophthalmic use).
Food interactions
No food interactions applicable (topical ophthalmic use).
Use in pregnancy
Use in Pregnancy: No adequate human data for use during pregnancy; use only if clearly needed.
Use in lactation
Use in Lactation: No data on presence in human milk; consider the benefits of breastfeeding and the mother's clinical need for the drug.
Pediatric use
Not recommended in pediatric patients aged 16 years and younger due to potential safety concerns related to increased pigmentation following long-term chronic use.
Geriatric use
No overall clinical differences in safety or effectiveness observed between elderly and other adult patients.
Renal / hepatic impairment
No specific precautions for renal or hepatic impairment (topical ophthalmic use).
Overdose effects
No specific overdose information available; symptomatic treatment.
Storage conditions
Unopened bottle: Store refrigerated at 2-8°C; Once opened: May be stored at 2-25°C for 8 weeks; Keep out of reach of children.
Chemical structure
Latanoprostene Bunod