Generic
Lornoxicam
11 brands available in the market
At a glance
Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) used for short-term relief of acute mild to moderate pain and symptomatic relief of pain and inflammation in osteoarthritis and rheumatoid arthritis.
Description
Lornoxicam is an NSAID and antirheumatic drug of the oxicam class. Its mode of action is mainly related to the inhibition of prostaglandin synthesis (inhibition of the cyclooxygenase enzyme), leading to desensitization of peripheral nociceptors and consequently inhibition of inflammation.
Indications
- Short-term relief of acute mild to moderate pain
- Symptomatic relief of pain and inflammation in osteoarthritis
- Symptomatic relief of pain and inflammation in rheumatoid arthritis
Therapeutic class
Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Pharmacological class
Oxicam-class NSAID
Pharmacology
Lornoxicam inhibits cyclooxygenase enzyme to prevent prostaglandin synthesis, leading to desensitization of peripheral nociceptors and inhibition of inflammation.
Mechanism of action
Reduces pain and inflammation by inhibiting prostaglandin synthesis.
Dosage
Acute Pain: 8-16 mg/day in 2-3 divided doses; max 16 mg/day
Osteoarthritis & Rheumatoid Arthritis: Initial 12 mg/day in 2-3 divided doses; maintenance max 16 mg/day
Renal/Hepatic Impairment (Mild-Moderate): Max 12 mg/day in 2-3 divided doses
Administration
- Swallow tablet whole; do not chew, crush or break
- Take with food (to reduce GI side effects)
Missed dose
Not generally applicable (short-term use); consult doctor if needed.
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Flatulence
- Constipation
- Dyspepsia
- Abdominal pain
- Melena
- Hematemesis
- Peptic ulcer
- GI bleeding (rare, especially in elderly)
Precautions & warnings
- Caution in patients with history of peptic ulcer or GI bleeding
- Caution in patients with impaired kidney function, history of hypertension or heart failure
- Caution in ulcerative colitis or Crohn's disease
- Caution in patients with history of bleeding tendency or asthma
- Caution in patients with SLE (Systemic Lupus Erythematosus)
Contraindications
- Hypersensitivity to Lornoxicam or excipients
- Peptic ulcer
- Severe hepatic impairment
- Severe renal impairment (Serum creatinine >700 pmol/l)
- Thrombocytopenia
- Third trimester of pregnancy
Drug interactions
- Increased risk of bleeding with Vitamin K antagonists (warfarin)
- Reduced kidney function with cyclosporin
- Increased adverse effects of lithium, methotrexate, and digoxin
- Reduced effect of diuretics, ACE inhibitors, and angiotensin II receptor antagonists (in heart failure patients)
Food interactions
No information on alcohol interaction; consult your doctor.
Use in pregnancy
Use in Pregnancy: No data in first and second trimesters; contraindicated in third trimester; should not be used during delivery.
Use in lactation
Use in Lactation: No data on excretion in human milk; excreted in rat milk at relatively high concentrations; should not be used in breastfeeding women.
Pediatric use
Not recommended for use in children and adolescents below age 18 due to lack of safety and efficacy data.
Geriatric use
No special dosage modification required for patients above age 65, but caution as gastrointestinal adverse effects are less well tolerated.
Renal / hepatic impairment
Renal Impairment: Mild-moderate: max 12 mg/day in 2-3 divided doses; severe: contraindicated.
Hepatic Impairment: Moderate: max 12 mg/day in 2-3 divided doses; severe: contraindicated.
Overdose effects
No overdose experience; nausea, vomiting, cerebral symptoms (dizziness, vision disturbances) may occur; gastric lavage; not dialyzable.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Lornoxicam