Nivolumab

Nivolumab is used in the treatment of non-small cell lung cancer, kidney cancer, head and neck cancer, melanoma, Hodgkin's disease, and liver cancer. Nivolumab is given as an infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include rash, weakness, headache, and fever. Some serious side effects which may occur during infusion include chills or shaking, itching, rash, flushing, difficulty breathing and dizziness. Hence, your doctor will check you timely after infusion for allergic reaction. Before taking it, tell your doctor if have lung disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy. Nivolumab is an anti-cancer medication. It works by blocking a protein (PD-1) on the surface of certain immune cells called T-cells. This action activates the T-cells to locate and kill cancer cells.

• Non-small cell lung cancer • Kidney cancer • Head and neck cancer • Melanoma • Hodgkin’s disease • Liver cancer

Nivolumab is an anti-cancer medication. It works by blocking a protein (PD-1) on the surface of certain immune cells called T-cells. This action activates the T-cells to locate and kill cancer cells.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Rash • Weakness • Headache • Fever • Musculoskeletal (bone, muscle or joint) pain • Back pain • Stomach pain • Nausea • Itching • Constipation • Diarrhea • Upper respiratory tract infection • Decreased appetite • Breathlessness • Cough

[SAFE] Nivolumab does not usually affect your ability to drive.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Nivolumab. Please consult your doctor.

[CONSULT YOUR DOCTOR] Nivolumab is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Nivolumab is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Nivolumab is safe to use in patients with kidney disease. No dose adjustment of Nivolumab is recommended. [SAFE IF PRESCRIBED] Nivolumab is safe to use in patients with liver disease. No dose adjustment of Nivolumab is recommended.

Store at 2-8° C (in a refrigerator). Do not freeze. Keep away from light and out of reach of children.

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