Generic
Silodosin
21 brands available in the market
At a glance
Silodosin is an alpha-1 adrenergic receptor antagonist used for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH). It relaxes muscles in the prostate and bladder to improve urine flow.
Description
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. Blockade of these receptors relaxes smooth muscle in these tissues, improving urine flow and reducing BPH symptoms.
Indications
- Signs and symptoms of Benign Prostatic Hyperplasia (BPH)
Therapeutic class
BPH/Urinary Retention/Urinary Incontinence
Pharmacological class
Alpha-1 Adrenergic Antagonist
Pharmacology
Silodosin blocks post-synaptic alpha-1 adrenoreceptors in the prostate, bladder base, bladder neck, prostatic capsule, and urethra. This blockade relaxes smooth muscle, reduces urethral resistance, and improves urine flow. It improves BPH symptoms such as difficulty starting urination, weak stream, and frequent urination.
Mechanism of action
Relaxes prostate and bladder muscles to improve urine flow.
Dosage
Adult Dose (Oral):
- Recommended: 8 mg once daily with a meal
- Moderate renal impairment (CrCl 30-50): 4 mg once daily
Administration
- Take with a meal
- Do not chew, crush, or break tablets
- Take at the same time each day
Missed dose
If you miss a dose, take it as soon as possible; if almost time for the next dose, skip it; do not double the dose.
Side effects
Common Side Effects:
- Retrograde ejaculation
- Orthostatic hypotension
- Dizziness, headache
- Nasal congestion
- Diarrhea
Precautions & warnings
- Postural hypotension (dizziness) may develop when starting treatment
- Do not use with other alpha-blockers
- Inform ophthalmologist before cataract surgery (IFIS risk)
- Do not use in severe renal or hepatic impairment
Contraindications
- Severe renal impairment (CrCl <30 mL/min)
- Severe hepatic impairment (Child-Pugh C)
- Concomitant use with strong CYP3A4 inhibitors (ketoconazole, clarithromycin, itraconazole, ritonavir)
- Hypersensitivity to silodosin
Drug interactions
- Strong P-glycoprotein inhibitors (cyclosporine): May increase silodosin plasma concentrations
- PDE5 inhibitors: May cause symptomatic hypotension
Food interactions
Alcohol is unsafe with Silodosin (excessive drowsiness).
Use in pregnancy
Use in Pregnancy: Silodosin is not indicated for women; generally safe; animal studies show low or no adverse effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Silodosin is not indicated for women; information not available; consult your doctor.
Pediatric use
Not indicated for pediatric patients
Geriatric use
No significant differences in safety or effectiveness between older and younger patients
Renal / hepatic impairment
Renal Impairment: Mild (CrCl 50-80): no dose adjustment; Moderate (CrCl 30-50): 4 mg/day; Severe (CrCl <30): contraindicated; consult your doctor.
Hepatic Impairment: Mild-moderate: no dose adjustment; Severe (Child-Pugh C): contraindicated; consult your doctor.
Overdose effects
Overdose may cause orthostatic hypotension; maintain supine position; consider IV fluids or vasopressors; dialysis is not effective (97% protein bound).
Storage conditions
Store below 30°C in a dry place, protected from light; keep out of reach of children.
Chemical structure
Silodosin