৳ 220/unit
Pack: ৳ 220
৳ 220/unit
Pack: ৳ 220
At a glance
Cefixime is a third generation cephalosporin antibiotic used to treat a variety of bacterial infections including respiratory tract infections, urinary tract infections, ear infections, throat infections, and some sexually transmitted diseases.
Indications
- Upper Respiratory Tract Infections (including otitis media)
- Lower Respiratory Tract Infections (bronchitis)
- Urinary Tract Infections (cystitis, pyelonephritis)
- Tonsillitis
- Pharyngitis
- Gonorrhea
- Typhoid fever
Pharmacology
Cefixime is a third generation semisynthetic cephalosporin antibiotic for oral administration. It is bactericidal against a broad spectrum of gram positive and gram negative bacteria at easily achievable plasma concentrations. It kills bacteria by interfering in the synthesis of bacterial cell wall. It is highly stable in the presence of Beta-lactamase enzyme. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to Cefixime. Absorption of it is about 40% to 50% whether administered with or without food.
Dosage
Adult Dose:
| Infection Type | Dose | Schedule | Duration |
|---|---|---|---|
| Acute Bronchitis, Acute Exacerbations of Chronic Bronchitis, Otitis Media, Pharyngitis/Tonsillitis, Uncomplicated UTI | 200 or 400 mg | Single dose or in two divided doses | Daily |
| Gonorrhea | 400 mg | Single dose | — |
| Typhoid fever | 20 mg/kg | Two divided doses | 7-14 days |
Pediatric Dose:
| Age/Weight | Dose | Schedule |
|---|---|---|
| 6 months-1 year | 75 mg/day | 1-2 divided doses |
| 1-4 years | 100 mg/day | 1-2 divided doses |
| 5-10 years | 200 mg/day | 1-2 divided doses |
| <50 kg | 8 mg/kg/day | q12-24h |
| Typhoid (Pediatric) | 15-20 mg/kg/day | q12hr |
Renal Dose: CrCl <20 ml/min: Maximum 200 mg daily.
Side effects
Common Side Effects:
- Nausea
- Stomach pain
- Indigestion
- Diarrhea
- Headache
- Dizziness
- Rash
- Pruritus
Use in pregnancy
[SAFE IF PRESCRIBED] Cefixime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [SAFE] Cefixime does not usually affect your ability to drive.
- Your doctor has prescribed Cefixime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
- Avoid consuming alcohol while taking Cefixime as it may cause increased side effects.
- Discontinue Cefixime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
- Cefixime should be given with caution to penicillin-sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and the cephalosporins.
- Treatment with broad spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of clostridia.
Overdose effects
Gastric Lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis.
Storage conditions
Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.