Gesta TS IM Injection
750mg/3mlRx৳ 750/unit
Pack: ৳ 750
৳ 750/unit
Pack: ৳ 750
At a glance
Hydroxyprogesterone Caproate is used to prevent premature labor in pregnant women with a history of spontaneous preterm birth.
Indications
- Reducing the risk of preterm birth (singleton pregnancy with history of spontaneous preterm birth)
- Prevention of preterm labor (patients aged 16 years or older with history of spontaneous preterm birth)
Pharmacology
Hydroxyprogesterone caproate is a synthetic steroid hormone similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone. Progesterone binds to progesterone receptors in the uterus, ovaries, breasts and central nervous system, leading to regulation of gene transcription. This results in an anti-inflammatory effect that blunts the proinflammatory state associated with labor initiation and maintains uterine quiescence by stabilizing progesterone action on the myometrium.
Dosage
Adult Dose (Intramuscular):
- Preterm Birth Prevention: 250 mg weekly (initiate between 16-20 weeks, continue until 37 weeks or delivery)
- Recurrent Miscarriage: 250-500 mg weekly during first half of pregnancy
- Amenorrhea/Abnormal Uterine Bleeding: Single dose 375 mg; may repeat at 4-week intervals if needed
- Endometrial Carcinoma: Usual dose: 1 g weekly (1-7 g/week)
Child Dose: Safety and efficacy not established
Side effects
Most Common:
- Injection site reactions (pain, swelling, pruritus, nodule)
- Hives
- Itching
- Nausea
- Diarrhea
Serious (Inform Doctor): Blood clot symptoms (leg swelling, redness, warmth, pain), allergic reactions (hives, itching, facial swelling)
Use in pregnancy
Use in Pregnancy: Category B; generally considered safe; animal studies show low or no adverse effects; limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Thromboembolic disorders: Discontinue if thrombosis or thromboembolism occurs
- Allergic reactions: Consider discontinuing if allergic reactions occur
- Decreased glucose tolerance: Monitor pre-diabetic and diabetic women
- Fluid retention: Monitor women with pre-eclampsia, epilepsy, cardiac or renal dysfunction
- Depression: Monitor with history of clinical depression; discontinue if recurs
- Jaundice and hypertension: Carefully monitor
Overdose effects
No adverse events associated with overdosage have been reported.
Storage conditions
Store at controlled room temperature between 15°C to 30°C; protect from light; keep out of reach of children.