৳ 15/unit
Pack: ৳ 15
৳ 15/unit
Pack: ৳ 15
At a glance
Ivermectin is an antiparasitic medication used for the treatment of strongyloidiasis, onchocerciasis, filariasis, scabies, and head lice.
Indications
- Strongyloidiasis (intestinal)
- Onchocerciasis
- Filariasis
- Scabies
- Head lice
Pharmacology
Ivermectin selectively binds with high affinity to glutamate-gated chloride ion channels, which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell and, ultimately, death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels.
Dosage
Adult Dose (Oral):
- Strongyloidiasis: 200 mcg/kg (single dose) on empty stomach
- Onchocerciasis: 150 mcg/kg (single dose) on empty stomach; usually 12-month intervals
- Scabies/Head Lice: 200 mcg/kg (single dose), repeat after 1 week
Child Dose: Safety and efficacy not established in patients weighing less than 15 kg
Side effects
Strongyloidiasis:
- Asthenia/fatigue (0.9%)
- Abdominal pain (0.9%)
- Anorexia (0.9%)
- Constipation (0.9%)
- Diarrhea (1.8%)
- Nausea (1.8%)
- Vomiting (0.9%)
- Dizziness (2.8%)
- Somnolence (0.9%)
- Vertigo (0.9%)
- Tremor (0.9%)
- Pruritus (2.8%)
- Rash (0.9%)
- Urticaria (0.9%)
Onchocerciasis: Arthralgia/synovitis (19.3%), lymph node enlargement and tenderness, pruritus (27.5%), fever (22.6%), abnormal eye sensation, eyelid edema, uveitis, conjunctivitis, keratitis
Use in pregnancy
Use in Pregnancy: Category C; safety not established; not selectively fetotoxic in animal studies; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Ivermectin does not usually affect your ability to drive
- Patients with onchocerciasis may experience Mazzotti reactions (cutaneous and systemic reactions)
- Risk of serious or fatal encephalopathy with Loa loa co-infection
- Caution in pregnancy and lactation
Overdose effects
Overdose: Nausea, vomiting, diarrhea, dizziness, ataxia, seizures, coma; symptomatic supportive treatment; gastric lavage.
Storage conditions
Store in a dry place, below 30°C; protect from light; keep out of reach of children.