৳ 95/unit
Pack: ৳ 950
৳ 95/unit
Pack: ৳ 950
At a glance
Fezolinetant is a neurokinin 3 (NK3) receptor antagonist used for the treatment of moderate to severe vasomotor symptoms due to menopause.
Indications
- Vasomotor Symptoms of Menopause: Used for treatment of moderate to severe hot flashes and night sweats due to menopause.
Pharmacology
Fezolinetant is a neurokinin 3 (NK3) receptor antagonist that blocks neurokinin B (NKB) binding on the kisspeptin/neurokinin B/dynorphin (KNDy) neuron to modulate neuronal activity in the thermoregulatory center. Fezolinetant has high affinity for the NK3 receptor.
Dosage
Adult Dose (Oral):
- One 45 mg tablet orally once daily with or without food.
- Swallow whole with liquids; do not cut, crush, or chew tablets.
- Administer at about the same time each day.
Side effects
Common Side Effects:
- Abdominal pain
- Diarrhea
- Difficulty sleeping
- Back pain
- Hot flashes
Signs of Liver Problems (Stop Fezolinetant):
- Nausea
- Vomiting
- Itching
- Yellowing of eyes or skin (jaundice)
- Pale feces
- Dark urine
- Pain in right upper abdomen
Use in pregnancy
Use in Pregnancy: No data on use in pregnant women; caution required.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Hepatic Transaminase Elevation and Hepatotoxicity: Elevations >3 times ULN occurred in clinical trials; perform hepatic lab tests prior to initiation; do not start if ALT or AST >=2 × ULN or total bilirubin >=2 × ULN; perform follow-up hepatic lab tests monthly for first 3 months, at 6 months, and 9 months after initiation.
Overdose effects
Overdose: Discontinue Fezolinetant therapy and institute appropriate symptomatic care.
Storage conditions
Storage: Store below 30 degree C. Keep away from light and out of reach of children.