৳ 9/unit
Pack: ৳ 90
৳ 9/unit
Pack: ৳ 90
At a glance
Metformin Hydrochloride is used for type 2 diabetes mellitus and polycystic ovary syndrome (PCOS). It lowers glucose production in the liver, delays glucose absorption from the intestines, and increases insulin sensitivity.
Indications
- Type 2 diabetes mellitus (especially in overweight patients) - monotherapy or in combination with other agents or insulin
- Polycystic ovary syndrome (PCOS)
Pharmacology
Metformin decreases hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis, delays intestinal glucose absorption, and enhances insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage
Immediate Release (Adult):
- Initial: 500 mg twice daily or 850 mg once daily (with meals)
- Gradually increase by 500 mg weekly to max 2,000 mg/day; up to 2,550 mg/day if needed
Extended Release (Adult):
- Initial: 500 mg once daily (with evening meal)
- Increase by 500 mg weekly to max 2,000 mg/day
Children (10 years+): 500 mg twice daily; gradually increase to 2,000 mg/day
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Taste disturbance
- Diarrhea
- Abdominal pain
- Loss of appetite
- Decreased vitamin B12 absorption (long-term use)
Use in pregnancy
Use in Pregnancy: Metformin is generally considered safe during pregnancy (Category B); animal studies have shown low or no adverse effects. However, insulin is preferred during pregnancy.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Inform doctor if symptoms of lactic acidosis occur (deep/rapid breathing, persistent nausea, vomiting, abdominal pain)
- Monitor blood sugar regularly to avoid hypoglycemia
- Avoid alcohol (risk of lactic acidosis)
- Temporarily stop before major surgery or contrast dye procedures
- Monitor vitamin B12 levels
Overdose effects
Overdose may cause lactic acidosis; hemodialysis is effective.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.