osudhkosh
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Company•Ambee Pharmaceuticals Ltd.

Myzid

150mg+300mgRx
Generic: Isoniazid + Rifampicin

৳ 1/unit

Pack: ৳ 1

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At a glance

Isoniazid + Rifampicin combination is used for the continuation phase treatment of tuberculosis (TB).

Indications
  • Tuberculosis (TB) - continuation phase treatment
Pharmacology

Rifampicin and isoniazid are active bactericidal anti-TB drugs which are particularly active against the rapidly growing extracellular organisms and also have bactericidal activity intracellularly. Rifampicin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Isoniazid acts against actively growing tubercle bacilli.

Dosage

Adult Dose (Oral):

  • Body weight <50 kg: 3 tablet of 150/100 once daily OR 1 tablet of 450/300 once daily
  • Body weight >50 kg: 2 tablet of 300/150 once daily
  • Hepatic impairment: Max: 8 mg/kg daily

Child Dose: Dose determined by physician based on weight

Side effects

Common Side Effects:

  • Dark colored urine (normal and harmless)
  • Rash
  • Vomiting
  • Jaundice
  • Fever
  • Increased liver enzymes
  • Nausea
  • Peripheral neuropathy (tingling and numbness of feet and hand)

Others: Tiredness, drowsiness, headache, dizziness, ataxia, mental confusion, muscular weakness, visual disturbances, leukopenia, thrombocytopenia

Use in pregnancy

Use in Pregnancy: May be unsafe; animal studies have shown harmful effects; doctor will weigh benefits and risks.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings

Precautions:

  • Isoniazid + Rifampicin may affect your ability to drive (seizures, mental problems, optic neuritis)
  • Regular monitoring of liver function tests advised
  • Avoid alcohol (may cause disulfiram reaction)
  • Inform doctor if signs of jaundice (yellowing of eyes or skin, dark urine, stomach pain)
  • Caution in kidney and liver disease
  • Hormonal contraceptives may be less effective (use additional contraceptive methods)
Overdose effects

Overdose: Nausea, vomiting, abdominal pain, dizziness, confusion, liver toxicity; seek emergency medical attention; gastric lavage and activated charcoal; symptomatic treatment.

Storage conditions

Keep below 30°C temperature, away from light & moisture; keep out of reach of children.

Isoniazid + Rifampicin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.