৳ 45/unit
Pack: ৳ 450
৳ 45/unit
Pack: ৳ 450
At a glance
Resmetirom is a thyroid hormone receptor-beta (THR-β) partial agonist used in conjunction with diet and exercise for the treatment of noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (F2-F3).
Indications
- Noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (F2-F3)
Pharmacology
Resmetirom is a selective partial agonist of THR-β that activates THR-β receptors in the liver, reducing intrahepatic triglycerides and improving liver fibrosis. It is more selective for THR-β compared to THR-α, reducing cardiovascular effects.
Dosage
Adult Dose (Oral):
- <100 kg: 80 mg once daily
- ≥100 kg: 100 mg once daily
- With moderate CYP2C8 inhibitors (<100 kg): 60 mg/day; (≥100 kg): 80 mg/day
- Can be taken with or without food
Side effects
Common Side Effects:
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Dizziness
- Pruritus
- Constipation
Use in pregnancy
Use in Pregnancy: No data on use in pregnant women; consult your doctor.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Hepatotoxicity: Monitor liver tests; discontinue if suspected
- Gallbladder-related adverse reactions (cholelithiasis, acute cholecystitis, obstructive pancreatitis): Interrupt treatment if suspected
- Drug interaction with statins: Dose adjustment needed for atorvastatin, pravastatin, rosuvastatin, simvastatin
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store below 30°C in a cool and dry place, away from light; keep out of reach of children.