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Company•Opsonin Pharma Limited

Rivadem 4.5

Rx
Generic: Rivaroxaban

৳ 60/unit

Pack: ৳ 600

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At a glance

Rivaroxaban is a direct factor Xa inhibitor used as an anticoagulant to reduce the risk of stroke and systemic embolism in nonvalvular atrial fibrillation, for treatment of DVT and PE, for reducing the risk of recurrence of DVT and PE, and for prophylaxis of DVT following knee or hip replacement surgery.

Indications
  • Reduction of stroke and systemic embolism in nonvalvular atrial fibrillation
  • Treatment of DVT and PE
  • Reduction of risk of recurrence of DVT and PE
  • Prophylaxis of DVT following knee or hip replacement surgery
Pharmacology

Rivaroxaban selectively inhibits factor Xa, disrupting the blood coagulation cascade and preventing thrombin formation. It does not require a cofactor such as antithrombin III. Dose-dependent inhibition of factor Xa activity is observed; it prolongs PT, aPTT, and HepTest.

Dosage

Adult Dose (Oral):

  • Nonvalvular AF (CrCl >50): 20 mg/day with evening meal
  • Nonvalvular AF (CrCl 15-50): 15 mg/day
  • DVT/PE treatment: 15 mg twice daily for 21 days, then 20 mg/day
  • DVT/PE recurrence prevention: 20 mg/day
  • Hip replacement: 10 mg/day for 35 days
  • Knee replacement: 10 mg/day for 12 days
  • ACS (2.5 mg): 2.5 mg twice daily + aspirin 75-100 mg/day
Side effects

Common Side Effects:

  • Bleeding (nosebleeds, bruising, gum bleeding)
  • Anemia
  • Nausea
  • Dizziness
  • Spinal or epidural hematoma (with neuraxial anesthesia)
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Bleeding risk: Caution in bleeding disorders, uncontrolled severe hypertension, GI disease
  • Discontinuation increases risk of thrombotic events
  • Spinal/epidural hematoma with neuraxial anesthesia
  • May affect driving ability (dizziness or fainting)
Overdose effects

Overdose may lead to hemorrhage; no specific antidote; activated charcoal to reduce absorption; partial reversal with plasma products.

Storage conditions

Store in a cool and dry place below 30°C, protected from light; keep out of reach of children.

Rivaroxaban — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.