৳ 40/unit
Pack: ৳ 240
৳ 40/unit
Pack: ৳ 240
At a glance
Rivastigmine is used for symptomatic treatment of mild to moderate dementia in Alzheimer's disease and dementia associated with Parkinson's disease. It is a cholinesterase inhibitor that increases acetylcholine levels in the brain, improving memory, awareness, and daily functioning.
Indications
- Mild to moderate dementia of Alzheimer's type
- Dementia associated with idiopathic Parkinson's disease
Pharmacology
Rivastigmine binds to and inactivates acetylcholinesterase and butyrylcholinesterase enzymes, preventing hydrolysis of acetylcholine. This leads to increased acetylcholine levels in the CNS, which improves cholinergic neurotransmission, memory, awareness, and ability to perform daily activities.
Dosage
Capsule (Adult):
- Initial: 1.5 mg twice daily (with morning and evening meals)
- Titration: Increase to 3 mg twice daily after 2 weeks; then to 4.5 mg and 6 mg twice daily based on tolerability
- Maintenance: 3-6 mg twice daily (maximum 6 mg twice daily)
Transdermal Patch:
- Initial: 4.6 mg/24 hours
- Titration: Increase to 9.5 mg/24 hours after 4 weeks; then to 13.3 mg/24 hours after additional 4 weeks if needed
Side effects
Common Side Effects:
- Nausea and vomiting (38% and 23%) – especially during dose titration
- Loss of appetite and weight loss
- Dizziness and headache
- Excessive sweating and weakness
- Abdominal pain and diarrhea
Use in pregnancy
Use in Pregnancy: Generally considered safe; animal studies show low or no adverse effects; limited human data; use if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in sick sinus syndrome or conduction defects
- Caution in asthma or obstructive pulmonary disease
- Caution in peptic ulcer and urinary obstruction
- Monitor body weight regularly
- Use in pregnancy only if clearly necessary
Overdose effects
Overdose may cause nausea, vomiting, diarrhea, hypertension, or hallucinations; atropine may be used; if asymptomatic, skip next dose for 24 hours.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.