Rosen 28 Plus
0.03mg/3mg/0.451mgRx৳ 14.75/unit
Pack: ৳ 413
৳ 14.75/unit
Pack: ৳ 413
At a glance
Ethinylestradiol + Drospirenone + Levomefolate Calcium is a combined oral contraceptive pill used for contraception, PMDD symptoms, acne, and raising folate levels.
Indications
- Contraception: Used as a combined oral contraceptive pill for prevention of pregnancy.
- PMDD: Used for treatment of symptoms of premenstrual dysphoric disorder.
- Acne: Used for treatment of moderate acne in women at least 14 years of age.
- Folate Supplementation: Used to raise folate levels in women using oral contraception (to reduce risk of neural tube defects).
Pharmacology
Ethinylestradiol is a synthetic version of oestrogen and Drospirenone is a synthetic form of progesterone. The hormonal components inhibit ovulation by suppressing gonadotropin release. Drospirenone has antimineralocorticoid activity, counteracting oestrogen related sodium retention. Drospirenone exerts antiandrogenic activity. Levomefolate Calcium is a metabolite of vitamin B9.
Dosage
Adult Dose:
- 1 tablet daily by mouth at the same time every day.
- 24 active orange tablets, then 4 light orange non-hormonal tablets.
- Start on the first day of menstruation (Day 1 Start) or first Sunday after onset (Sunday Start).
Side effects
Common Side Effects (>=2%):
- Headache/migraine (5.9%)
- Menstrual irregularities (4.1%)
- Nausea/vomiting (3.5%)
- Breast pain/tenderness (3.2%)
- Fatigue (4.2%)
- Irritability (2.8%)
- Decreased libido (2.8%)
- Weight gain (2.5%)
In PMDD trials: Menstrual irregularities (24.9%), nausea (15.8%), headache (13.0%), breast tenderness (10.5%).
Use in pregnancy
Use in Pregnancy: Do not use during pregnancy. If pregnancy occurs, discontinue.
Pregnancy Category: B3 — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Vascular risks: Stop if thrombotic event occurs; stop 4 weeks before major surgery and start 2 weeks after.
- DRSP-containing COCs may be associated with higher risk of VTE.
- Hyperkalemia: DRSP has antimineralocorticoid activity; do not use in patients predisposed to hyperkalemia.
- Liver disease: Discontinue if jaundice occurs.
- High blood pressure: Do not prescribe for women with uncontrolled hypertension.
- Lactation: When possible, advise nursing mother to use other forms of contraception until weaned.
Overdose effects
Overdose: Overdose may cause nausea, vomiting, breast tenderness, dizziness, abdominal pain, drowsiness, fatigue; withdrawal bleeding may occur in females. No specific antidote; symptomatic treatment.
Storage conditions
Storage: Keep below 30 degree C, away from light and moisture. Keep out of reach of children.