৳ 4/unit
Pack: ৳ 40
৳ 4/unit
Pack: ৳ 40
At a glance
Aripiprazole is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, major depressive disorder (as adjunct), and irritability associated with autistic disorder.
Indications
- Schizophrenia
- Bipolar disorder (manic or mixed episodes)
- Major depressive disorder (adjunctive treatment)
- Irritability associated with autistic disorder
- Agitation associated with schizophrenia or bipolar mania
Pharmacology
Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT1A receptors and antagonist activity at Serotonin 5-HT2A receptors.
This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.
Dosage
Schizophrenia:
- Adults: Initial: 10-15 mg/day, Recommended: 10-15 mg/day, Maximum: 30 mg/day
- Adolescents (13-17 years): Initial: 2 mg/day → 5 mg/day after 2 days → 10 mg/day after 2 more days, Maximum: 30 mg/day
Bipolar Mania:
- Adults (Monotherapy): Initial: 15 mg/day, Maximum: 30 mg/day
- Adults (Adjunct to lithium/valproate): Initial: 10-15 mg/day, Recommended: 15 mg/day, Maximum: 30 mg/day
- Pediatric (10-17 years): Initial: 2 mg/day → 5 mg/day after 2 days → 10 mg/day after 2 more days, Maximum: 30 mg/day
Major Depressive Disorder (Adjunct):
- Initial: 2-5 mg/day, Recommended: 5-10 mg/day, Maximum: 15 mg/day
Irritability in Autistic Disorder (6-17 years):
- Initial: 2 mg/day → 5 mg/day (within 1 week), Maximum: 15 mg/day
Tourette Disorder (6-18 years):
- <50 kg: 2 mg/day → 5 mg/day after 2 days → up to 10 mg/day if needed
- ≥50 kg: 2 mg/day (2 days) → 5 mg/day (5 days) → 10 mg/day (Day 8), Maximum: 20 mg/day
Special Populations: No dose adjustment needed in renal impairment. No dose adjustment likely needed in hepatic impairment.
Side effects
- Akathisia (inability to stay still)
- Anxiety
- Blurred vision
- Constipation
- Dizziness
- Fatigue
- Headache
- Increased saliva production
- Indigestion
- Insomnia (difficulty in sleeping)
- Nausea
- Parkinsonism
- Restlessness
- Sleepiness
- Tremor
- Vomiting
- Extrapyramidal disorder
- Sedation
- Pyrexia
- Decreased appetite
Use in pregnancy
[CONSULT YOUR DOCTOR] Aripiprazole may be unsafe to use during pregnancy (Pregnancy Category C). Animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and potential risks before prescribing. Should be avoided during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- Increased incidence of cerebrovascular adverse events (stroke, TIA, including fatalities) in elderly patients with dementia-related psychosis
- Increased risk of suicidality in children, adolescents, and young adults with major depressive disorder
- Tardive dyskinesia - discontinue if clinically appropriate
- Metabolic changes: hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain - monitor blood sugar and cholesterol regularly
- Orthostatic hypotension - caution in patients with known cardiovascular or cerebrovascular disease
- Seizures - use cautiously in patients with a history of seizures
- Caution when operating machinery - may cause dizziness and sleepiness
- Do not stop suddenly - may worsen symptoms
- Caution during pregnancy and lactation - animal studies have shown harmful effects on the developing baby
- Inform your doctor if you notice sudden mood changes, unusual movements or develop suicidal thoughts
Overdose effects
Aripiprazole at doses up to 1080 mg caused no fatalities. Signs and symptoms of overdose include nausea, vomiting, asthenia, diarrhea, and somnolence.
Storage conditions
Keep below 30°C, away from light & moisture. Keep out of reach of children.