Lenalidomide

Lenalidomide is used in the treatment of multiple myeloma and lepra reaction. This medicine belongs to a group of medicines which affect how your immune system works. Lenalidomide can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Some common side effects of this medicine include headache, weakness, nausea, rash, and dizziness. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections or bleeding. Hence, take caution while performing the activity that might increase your chances of bleeding or avoid contact with people suffering from infection such as cold. Regular blood tests are required to check your blood cells while on treatment. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. You are advised to drink plenty of fluids to stay hydrated while taking this medicine. Lenalidomide is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.

• Multiple myeloma • Lepra reaction

Lenalidomide, a thalidomide analogue, is an immunomodulatory agent w/ antiangiogenic and antineoplastic property. It inhibits proinflammatory cytokines secretion, increases interleukin-2 and interferon-γ secretion, and increases cytolytic T-cell and natural killer cell response. It also inhibits the growth of myeloma cells by inducing cell cycle arrest and cell death.

Adult Dose: Oral Myelodysplastic disease Adult: Initially, 10 mg once daily for 21 consecutive days of repeated 28-day cycle. Multiple myeloma Adult: In combination w/ dexamethasone. Lenalidomide: Initially, 25 mg once daily for 21 consecutive days of repeated 28-day cycle. Dexamethasone: 40 mg once daily on days 1-4, 9-12 and 17-20 of each 28-day cycle, for the 1st 4 cycles, then 40 mg once daily on days 1-4 of each 28-day cycle. Elderly: No dosage adjustment needed. Child Dose: <18 years old: Safety and efficacy not established Renal Dose: Myelodysplastic disease: Moderate: 5 mg once daily. Severe (not requiring dialysis): 5 mg every other day. End-stage renal disease: 5 mg 3 times/wk after dialysis. Multiple myeloma: Moderate: 10 mg once daily may be increased to 15 mg once daily after 2 cycles if needed. Severe (not requiring dialysis): 15 mg every other day, may be increased to 10 mg once daily if needed. End-stage renal disease: 5 mg once daily after dialysis.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Lenalidomide may be taken with or without food, but it is better to take it at a fixed time.

Common: • Headache • Weakness • Nausea • Rash • Dizziness • Sleepiness • Edema (swelling) • Loss of appetite • Decreased white blood cell count • Decreased calcium level in blood • Weight gain • Muscle weakness • Fatigue • Fever • Anxiety • Blood clots • Dry skin • Weight loss • Confusion • Decreased white blood cell count (neutrophils) • Neuropathy • Constipation • Tremor

[UNSAFE] Lenalidomide may cause side effects which could affect your ability to drive. You may feel dizzy, tired, sleepy, have vertigo or blurred vision after taking Lenalidomide and this may affect your ability to drive. You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting. Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections. It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out. It may cause dehydration. Drink plenty of water to stay hydrated while taking medication. It is not recommended for use in children and adolescents under 18 years. You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment. Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment. You should inform your doctor or dentist that you are taking Lenalidomide before you receive any medical or dental care, emergency care, or surgery. It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. You may be at risk of developing acute myelogenous leukemia, Hodgkin lymphoma tumor lysis syndrome, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Lenalidomide. You should discuss in advance the benefits and risks of taking this medicine.

Pregnancy and lactation; sexually active women of childbearing potential not using 2 forms of contraception. Demonstrated hypersensitivity (eg, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis)

May increase risk of thrombosis w/ erythropoietic agents. May increase plasma concentration of digoxin, ketoconazole, itraconazole, ciclosporin, verapamil, quinidine, clarithromycin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Lenalidomide. Please consult your doctor.

[UNSAFE] Lenalidomide is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[CONSULT YOUR DOCTOR] Lenalidomide is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Lenalidomide should be used with caution in patients with kidney disease. Dose adjustment of Lenalidomide may be needed. Please consult your doctor. [CAUTION] Lenalidomide should be used with caution in patients with liver disease. Dose adjustment of Lenalidomide may be needed. Please consult your doctor.

Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process. U r having multiple myeloma Multiple myeloma can be cured or not Yes, if diagnosed at the right stage Pus disharge from maxilla.Patient has multiple myeloma Tooth exfoliated from the jaw post which this change was noted OPG reveals radiolucency in that site Visit to a dentist for proper treatment by surgery. Report shows higher esr value what should i do. A very high ESR usually has an obvious cause, such as a severe infection, marked by an increase in globulins, polymyalgia rheumatica or temporal arteritis. A health practitioner will typically use other follow-up tests, such as blood cultures, depending on the person&#x27;s symptoms. People with multiple myeloma or Waldenstrom&#x27;s macroglobulinemia (tumors that make large amounts of immunoglobulins) typically have very high ESRs even if they don&#x27;t have inflammationNeed to correlate clinicallyKindly consult your doctor Some time allergic reaction cetcip 10 mg twice daily for 3 days Ganral enquiries about daly sex How to increase the reaction time take healthy food, more of urad daal, dry fruits, will help. Ashwgandha capsule 2 capsule twice with milk will help What is LENALIDOMIDE & why should it be taken ? Lenalidomide is a anti myeloma medicine i am having an allergy of sneezing and i had consulted doctor and dr. had given zeclox capsule and ellervil tablet so i want to know that is there any substitute of zeclox capsule bcoz its not available in local market or can u make zeclox capsule available on 1mg app? i&#x27;ll buy it in bulk Zeclox is combination of amoxicylline and dicloxacilline so u can search with salt and u will get multiple brands