৳ 20/unit
Pack: ৳ 20
৳ 20/unit
Pack: ৳ 20
At a glance
Sparfloxacin is a fluoroquinolone antibiotic used for community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, sinusitis, urinary tract infections, and other bacterial infections.
Indications
- Community-acquired pneumonia (CAP)
- Acute bacterial exacerbation of chronic bronchitis (ABECB)
- Chronic Obstructive Pulmonary Disease (COPD)
- Acute maxillary sinusitis (AMS)
- Urinary tract infections (gonococcal and nongonococcal urethritis, chancroid)
- Bacterial prostatitis
- Bacterial diarrhea
- Osteomyelitis
- Tuberculosis (with rifampicin and isoniazid)
Pharmacology
Sparfloxacin inhibits bacterial DNA gyrase and topoisomerase IV enzymes, preventing DNA supercoiling, which breaks DNA structures and stops bacterial cell division and repair.
Dosage
Adult Dose (Oral):
- Loading dose: 400 mg (2 tablets) on the first day
- Maintenance: 200 mg (1 tablet) daily for 10 days
- Renal impairment (CrCl <50): Loading 400 mg; then 200 mg every 48 hours (9 days)
Side effects
Common Side Effects:
- Photosensitivity reaction
- Diarrhea, nausea, dyspepsia
- Headache, dizziness, insomnia
- Abdominal pain, pruritus, taste perversion
- QTc interval prolongation
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Phototoxic reactions: Avoid direct or indirect sunlight or artificial UV light
- QTc prolongation: Caution with drugs that prolong QTc
- Do not use in pregnancy and lactation
- Safety not established in children <18 years
Overdose effects
No overdose information available; excessive doses may increase side effects; consult your doctor.
Storage conditions
Keep out of reach of children; store away from heat and direct light; store below 30°C.