Vaccine(unkonown)2.5IU/ml

• Pre-exposure immunization (high-risk professionals: veterinarians, laboratory personnel, forestry workers)
• Post-exposure immunization (bite or contact with rabid animal)

Pre-exposure Immunization (IM):

• Primary: 1 ml IM on D0, D7, D21 or D28; booster at 1 year
• Boosters: Every 5 years or when titre <0.5 IU/ml

Post-exposure Immunization (Non-immunized):

• IM (1-1-1-1-1): 1 ml on D0, D3, D7, D14, D28
• IM (2-1-1): 2 ml (1 ml each) on D0; 1 ml on D7 and D21
• ID (Thai Red Cross 2-2-2-0-1-1): 2x0.1 ml on D0, D3, D7; 0.1 ml on D28; 0.1 ml on D90 (optional)
• ID (WHO Modified 2-2-2-0-2): 2x0.1 ml on D0, D3, D7, D28

Post-exposure (Previously Immunized):

• If <5 years: 2 injections on D0 and D3
• If >5 years or incomplete: 5 injections (D0, D3, D7, D14, D28) + immunoglobulin if needed

Side Effects (>10%):

• Injection site pain, redness, swelling, itching (30-74%)
• Nausea/vomiting (5-40%)
• Abdominal pain, diarrhea (5-40%)
• Headache, fatigue (5-40%)
• Low-grade fever, chills, muscle ache, dizziness (5-40%)

• Immune complex reaction 2-21 days after HDCV booster doses (arthralgia, arthritis, angioedema)
• Caution in bleeding disorders, anticoagulant treatment, severely immunocompromised patients
• Do not use in confirmed rabies diagnosis
• Pre-exposure: Contraindicated in severe fever, febrile infection, acute disease
• Post-exposure: No contraindication (rabies is lethal)