Generic
Rabies Vaccine (Human) BP
4 brands available in the market
At a glance
Rabies Vaccine (Human) BP is an inactivated virus vaccine used for active immunization against rabies. It can be used for pre- and post-exposure immunization and is often used with rabies immunoglobulin for post-exposure immunization.
Description
Rabies Vaccine is a freeze-dried preparation of inactivated rabies virus produced on Vero cells. After reconstitution, the vaccine is a clear, colorless sterile solution for intramuscular use. It provides active immunization and is indicated for pre-exposure (high-risk professionals) and post-exposure (bite or contact with rabid animal).
Indications
- Pre-exposure immunization (high-risk professionals: veterinarians, laboratory personnel, forestry workers)
- Post-exposure immunization (bite or contact with rabid animal)
Pharmacological class
Inactivated Virus Vaccine (Cell Culture)
Pharmacology
Rabies Vaccine is an inactivated virus vaccine that stimulates antibody production against the rabies virus, providing active immunization. For post-exposure immunization, it takes about 7-10 days for specific antibodies to develop, so it is often used with rabies immunoglobulin.
Mechanism of action
Stimulates antibody production against rabies virus.
Dosage
Pre-exposure Immunization (IM):
- Primary: 1 ml IM on D0, D7, D21 or D28; booster at 1 year
- Boosters: Every 5 years or when titre <0.5 IU/ml
Post-exposure Immunization (Non-immunized):
- IM (1-1-1-1-1): 1 ml on D0, D3, D7, D14, D28
- IM (2-1-1): 2 ml (1 ml each) on D0; 1 ml on D7 and D21
- ID (Thai Red Cross 2-2-2-0-1-1): 2x0.1 ml on D0, D3, D7; 0.1 ml on D28; 0.1 ml on D90 (optional)
- ID (WHO Modified 2-2-2-0-2): 2x0.1 ml on D0, D3, D7, D28
Post-exposure (Previously Immunized):
- If <5 years: 2 injections on D0 and D3
- If >5 years or incomplete: 5 injections (D0, D3, D7, D14, D28) + immunoglobulin if needed
Administration
- Use immediately after reconstitution
- IM: Deltoid in adults, anterolateral thigh in children under 1 year
- Do not inject into gluteal region
- Do not inject intravenously
- ID: Upper arm, over deltoid
Missed dose
If you miss a dose, consult your doctor.
Drug interactions
- Immunosuppressants: May reduce vaccine efficacy
Food interactions
It is not known whether it is safe to consume alcohol with Rabies Vaccine.
Contraindications
- Pre-exposure: Severe fever, febrile infection, acute disease, progressive chronic diseases; hypersensitivity to rabies vaccine or any component
- Post-exposure: No contraindication (rabies is lethal)
Side effects
Side Effects (>10%):
- Injection site pain, redness, swelling, itching (30-74%)
- Nausea/vomiting (5-40%)
- Abdominal pain, diarrhea (5-40%)
- Headache, fatigue (5-40%)
- Low-grade fever, chills, muscle ache, dizziness (5-40%)
Use in pregnancy
Use in Pregnancy: Potential risk during pregnancy is unknown; however, due to severity of disease, pregnancy is not a contraindication to post-exposure prophylaxis.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Unknown if vaccine is excreted in breast milk; due to severity of disease, breastfeeding is not a contraindication.
Precautions & warnings
- Immune complex reaction 2-21 days after HDCV booster doses (arthralgia, arthritis, angioedema)
- Caution in bleeding disorders, anticoagulant treatment, severely immunocompromised patients
- Do not use in confirmed rabies diagnosis
- Pre-exposure: Contraindicated in severe fever, febrile infection, acute disease
- Post-exposure: No contraindication (rabies is lethal)
Pediatric use
Pediatric dose same as adult; under 1 year, give IM in anterolateral thigh.
Geriatric use
No dose adjustment required for elderly patients.
Renal / hepatic impairment
Renal Impairment: Safe in kidney disease; dose adjustment may not be needed; consult your doctor.
Hepatic Impairment: Safe in liver disease; dose adjustment may not be needed; consult your doctor.
Overdose effects
No overdose information available; consult your doctor if overused.
Therapeutic class
Vaccines, Anti-sera & Immunoglobulin
Storage conditions
Store and transport at 2-8°C; protect from light; do not keep in deep freeze; use within 8 hours after reconstitution or discard; keep out of reach and sight of children.
Chemical structure
Rabies Vaccine (Human) BP