Adapalene + Clindamycin Phosphate

Adapalene + Clindamycin Phosphate Gel is a prescription-strength topical treatment designed to effectively manage acne. This dual-action formula targets both inflammatory and non-inflammatory acne, helping to unclog pores, reduce redness, and prevent future breakouts. Adapalene (0.1%) in microsphere technology ensures controlled release for better tolerability. Clindamycin Phosphate (1%) reduces the growth of acne-causing bacteria. It is dermatologist-recommended and effective for stubborn acne

Used for the treatment of acne vulgaris

Topical Retinoid + Topical Antibiotic (Combination)

Adapalene is a retinoid that normalizes skin cell turnover and prevents comedone formation. Clindamycin Phosphate is an antibiotic that kills acne-causing bacteria (Propionibacterium acnes) by inhibiting bacterial protein synthesis .

Adapalene helps remove dead skin cells and keep pores open, preventing new acne formation. Clindamycin Phosphate stops bacterial growth and reduces inflammation. Together, they target multiple causes of acne .

Adults and children over 12 years: Apply a thin layer to clean, dry skin once daily at night . During the first week of treatment, acne may worsen (initial exacerbation), which is normal. Therapeutic effect is observed 8-12 weeks after starting treatment

Apply a thin layer of gel to affected areas after cleansing and drying the skin. Avoid contact with eyes, mouth, nose, and mucous membranes. Wash hands thoroughly after application

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule

Common Side Effects: • Redness (Erythema) • Peeling • Dryness • Itching (Pruritus) • Burning or stinging sensation • Application site irritation Serious Side Effects (Rare – Consult Doctor): • Allergic reactions (Anaphylaxis, Angioedema, Urticaria) • Diarrhea • Bloody diarrhea • Colitis (including pseudomembranous colitis) • Severe skin irritation or contact dermatitis

Avoid contact with eyes, lips, areas of the nose, and mucous membranes . Do not apply to eczematous skin lesions, sunburns, cuts, or other skin lesions . Avoid excessive sunlight and UV light (tanning beds, sun lamps) during treatment due to increased skin sensitivity . Contraindicated in patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis . Discontinue use if significant diarrhea occurs . Consult your doctor during pregnancy and breastfeeding.

Hypersensitivity to adapalene, clindamycin, or other components . History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis .

Concomitant use of other potentially irritating topical products (peeling, desquamating, abrasive agents, high alcohol products) may cause excessive irritation . Use with concomitant topical acne therapy has not been evaluated .

Available data with this combination in pregnant women are insufficient. Clindamycin has not been associated with major birth defects. Adapalene animal studies at high oral doses showed fetal malformations . Use during pregnancy only if clearly needed and with medical advice.

It is not known whether topical clindamycin or adapalene is excreted in human milk. Clindamycin is excreted following oral and parenteral administration. Use with caution .

Can be used in children above 12 years . Safety and efficacy have not been established in children under 12 years.

No specific information is available for geriatric use. Adult dosage applies. Caution regarding sun sensitivity and skin irritation.

Possible redness and peeling of the skin when excessive amounts of gel are applied. Therapy is symptomati

Store below 30°C, protected from light. Keep out of reach of children. Do not use after the expiry date.