Generic
Aluminium Hydroxide + Magnesium Hydroxide
40 brands available in the market
At a glance
Aluminium Hydroxide + Magnesium Hydroxide is a combination antacid used to neutralize excess stomach acid and treat heartburn, indigestion, gastritis and peptic ulcer.
Description
Aluminium Hydroxide + Magnesium Hydroxide is a well-balanced non-systemic antacid combination that excels in efficacy and palatability. Aluminium hydroxide is a slow-acting antacid and adsorbent with prolonged effect and high neutralizing power. Magnesium hydroxide provides slow but sustained acid neutralizing properties. This combination provides symptomatic relief of hyperacidity associated with heartburn, acid ingestion or sour stomach without acid rebound, constipating or cathartic effects. Aluminium hydroxide's adsorbent property forms a protective coating over the ulcer surface facilitating healing and protecting the sensitive mucosa of stomach and duodenum from further irritation.
Indications
Hyperacidity, peptic ulcer, gastritis, heartburn, sour stomach, dyspepsia, reflux oesophagitis.
Therapeutic class
Antacid
Pharmacological class
Aluminium-Magnesium based Antacid
Pharmacology
Aluminium hydroxide is a slow-acting antacid and adsorbent with prolonged effect and high neutralizing power. Magnesium hydroxide provides slow but sustained acid neutralizing properties. Aluminium hydroxide forms a protective coating over the ulcer surface to facilitate healing. Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, resulting in bowel evacuation.
Mechanism of action
Aluminium hydroxide neutralizes gastric HCl to form aluminium chloride and water, and forms a protective coating over the ulcer surface. Magnesium hydroxide reduces stomach acid by reacting with hydrochloric acid to form magnesium chloride and increases peristaltic activity.
Dosage
Tablet: 2 tablets 1-3 hours after meals and at bedtime, or as directed by the physician.
Suspension: 2 teaspoonfuls (10 mL) 1-3 hours after meals and at bedtime, or as directed by the physician.
Gastric Hyperacidity/Heartburn: Up to 1 g/day.
Hyperphosphataemia in Chronic Renal Failure: Up to 10 g/day in divided doses with meals.
Administration
May be taken with or without food (preferably 1-3 hours after meals or at bedtime).
Administer 2 hours before or after other medications to minimize drug interactions.
Missed dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Side effects
Common side effects:
- Aluminium hydroxide: Chalky taste, constipation, fecal impaction, stomach cramps
- Magnesium hydroxide: Diarrhea
With long-term use: Alkaluria (may predispose to nephrolithiasis by forming calcium phosphate precipitation)
Serious (rare): Aluminium intoxication (in chronic renal failure), hypophosphataemia, osteomalacia, hypermagnesaemia, alkalosis.
Precautions & warnings
- Caution in chronic renal impairment (risk of aluminium accumulation)
- Caution in congestive heart failure, oedema, cirrhosis, and low sodium diets
- Caution in patients with recent gastrointestinal haemorrhage
- Maintain 2 hour gap with other medications (to avoid absorption interference)
- Avoid use in the first trimester of pregnancy
- Caution during lactation
Contraindications
- Hypophosphataemia
- Alkalosis
- Hypermagnesaemia (where abdominal distention may be due to partial or complete intestinal obstruction)
- Hypersensitivity to aluminium or magnesium salts
Drug interactions
- Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid; decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, bisphosphonates, corticosteroids, cyclosporine, delavirdine, iron salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine
- Magnesium Hydroxide: Decreases absorption of tetracyclines and bisphosphonates
- Azithromycin, cefpodoxime, ciprofloxacin, isoniazid, rifampicin, norfloxacin, ofloxacin, pivampicillin, gabapentin, phenytoin, itraconazole, ketoconazole, chloroquine, hydroxychloroquine, phenothiazines: Decreased absorption
Food interactions
Calcium-rich foods (e.g., milk) may increase aluminium absorption. Citrus fruits increase aluminium absorption.
Use in pregnancy
It is advised to avoid antacid preparations in the first trimester of pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
There is insufficient information on the use of aluminium hydroxide + magnesium hydroxide during lactation. Use with caution.
Pediatric use
Use in children as directed by a physician.
Geriatric use
No dose adjustment needed for elderly patients; however, constipation and electrolyte imbalance risks are higher.
Renal / hepatic impairment
Renal impairment: Caution in chronic renal impairment (risk of aluminium accumulation, encephalopathy, and osteomalacia). Hypermagnesaemia may occur.
Hepatic impairment: Caution in cirrhosis patients (may be on a low sodium diet).
Overdose effects
Overdose symptoms: severe constipation, intestinal obstruction, diarrhea, electrolyte imbalance. Treatment: drug discontinuation and symptomatic measures.
Storage conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Chemical structure
Aluminium Hydroxide + Magnesium Hydroxide