Generic
Amino Acid 8%
5 brands available in the market
At a glance
Amino Acid 8% is a parenteral nutrition solution used for parenteral amino acid supply in severe forms of hepatic failure (liver insufficiency) with and without encephalopathy, when oral or enteral nutrition is impossible, insufficient or contraindicated.
Description
Amino Acid 8% is a parenteral nutrition solution used for parenteral amino acid supply in severe hepatic failure (liver insufficiency) with and without encephalopathy. This solution contains a specific composition of essential amino acids suitable for patients with liver disease. It is used when oral or enteral nutrition is impossible, insufficient or contraindicated. Each 1000 mL contains specific amounts of various amino acids to support protein synthesis and metabolic needs in the body.
Indications
Parenteral amino acid supply in severe forms of hepatic failure (liver insufficiency) with and without encephalopathy; when oral or enteral nutrition is impossible, insufficient or contraindicated.
Therapeutic class
Parenteral Nutritional Preparations
Pharmacological class
Amino Acid Solution (Hepatic Specialized)
Pharmacology
Amino Acid 8% solution contains a specific composition of essential amino acids suitable for patients with liver disease. It is administered parenterally when patients cannot take oral or enteral nutrition. Amino acids are essential for protein synthesis, tissue repair and growth, and maintaining nitrogen balance. In liver disease, amino acid metabolism is impaired, so this specialized composition helps meet the metabolic needs of liver patients.
Mechanism of action
Amino Acid 8% provides a specialized amino acid composition suitable for patients with liver disease, supporting protein synthesis, tissue repair and nitrogen balance.
Dosage
Adults: 1.0-1.25 ml/kg/hour IV infusion.
Maximum dosage: 1.5 g amino acids/kg/day = 1300 ml/day at 70 kg body weight.
Administration
For intravenous infusion only.
Constant monitoring of serum electrolytes, fluid balance and acid-base balance is mandatory.
Missed dose
Missed dose is not applicable as it is administered by a healthcare professional in a hospital setting.
Side effects
Side effects: Use in indications other than those recommended may result in amino acid imbalances and severe metabolic disorders.
Injection site reactions, flushing, nausea, vomiting, electrolyte imbalance may occur.
Precautions & warnings
- Constant monitoring of serum electrolytes, fluid balance and acid-base balance required
- Regular monitoring of liver function required
- Do not mix with other drugs (risk of microbial contamination and incompatibilities)
Contraindications
- Disturbance of amino acid metabolism
- Metabolic acidosis
- Fluid overload
- Hyponatremia
- Hypokalemia
- Renal insufficiency
- Decompensated cardiac insufficiency
- Shock
- Hypoxia
- Hypersensitivity to amino acids or any component
Drug interactions
Other drugs: Due to the risk of microbial contamination and incompatibilities, Amino Acid 8% should not be mixed with other drugs. If it becomes necessary to add carbohydrates, lipid emulsions, electrolytes, vitamins or trace elements, care should be given to hygienic admixing, good blending and compatibility.
Food interactions
Information on alcohol consumption is not available; consult your doctor.
Use in pregnancy
No specific studies have been performed to assess the safety of Amino Acid 8% during pregnancy. Use only if clearly needed with medical advice.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
No specific studies have been performed to assess the safety of Amino Acid 8% during lactation. Use with caution.
Pediatric use
Safety and effectiveness in pediatric patients have not been established.
Geriatric use
Geriatric doses are individualized (considering kidney and liver function).
Renal / hepatic impairment
Renal impairment: Contraindicated in renal insufficiency.
Hepatic impairment: Indicated in severe hepatic failure; however, regular monitoring of liver function is required.
Overdose effects
Overdose symptoms: electrolyte imbalance, metabolic acidosis, fluid overload. Treatment: symptomatic and supportive measures.
Storage conditions
Do not store Amino Acid 8% after addition of other components.
Do not store above 25°C. Do not freeze.
Shelf Life: 36 months. Do not use after expiry date. Do not use if solution is cloudy or container is damaged.
Keep out of reach of children.
Chemical structure
Amino Acid 8% Solution